DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Jung, Inkyung | - |
dc.contributor.advisor | 정인경 | - |
dc.contributor.author | Eom, Jung Hyun | - |
dc.date.accessioned | 2023-06-23T19:31:20Z | - |
dc.date.available | 2023-06-23T19:31:20Z | - |
dc.date.issued | 2019 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=1021038&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/308819 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 생명과학과, 2019.8,[iv, 48 p. :] | - |
dc.description.abstract | Variation in immune system, marked by distinct composition of immune cell types and protein levels, has been observed between healthy individuals. However, such variation is yet to be characterized at the level of gene regulation within one homogeneous cell type. Here, I profile gene expression, chromatin accessibility, genotypes, and higher-order chromatin structure of classical human blood monocytes across 24 healthy individuals of the same ethnicity to delineate individual-specific gene regulation mechanisms. I revealed that 40% of expressed genes in monocytes exhibit individual-specific expression pattern and I hypothesized such variation is mediated by cis-regulatory elements (cRE). Therefore, I utilized high resolution Hi-C data to identify significantly interacting cRE-promoter pairs to annotate distal cRE to target genes. My analysis show that gene expression could be explained by variation in chromatin accessibility of cRE and a fraction of its activity was driven by individual genotype. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | Individual variation▼aCis-regulatory elements▼aEpigenetics▼aGene regulation▼aMonocytes | - |
dc.subject | 개인간 차이▼a시스-조절인자▼a후성유전학▼a유전자 조절▼a단핵세포 | - |
dc.title | Epigenetic gene regulation of inter-individual variability | - |
dc.title.alternative | 후성유전적 유전자 발현조절에 의한 개인간 다양성 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :생명과학과, | - |
dc.contributor.alternativeauthor | 엄정현 | - |
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