DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Han, Jin-Hee | - |
dc.contributor.advisor | 한진희 | - |
dc.contributor.author | Kang, Min Soo | - |
dc.date.accessioned | 2023-06-22T19:33:20Z | - |
dc.date.available | 2023-06-22T19:33:20Z | - |
dc.date.issued | 2022 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=996329&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/308471 | - |
dc.description | 학위논문(박사) - 한국과학기술원 : 생명과학과, 2022.2,[iii, 83 p. :] | - |
dc.description.abstract | Formation of temporal association memory and context-specific fear memory is thought to require medial entorhinal cortex (MEC) inputs to the hippocampus during learning events. However, whether the MEC inputs are also involved in memory formation during a post-learning period has not been directly tested yet. To examine this possibility, I optogenetically inhibited axons and terminals originating from bilateral dorsal MEC excitatory neurons in the dorsal hippocampus for 5 min right after contextual fear conditioning (CFC). Mice expressing eNpHR3.0 exhibited significantly less freezing compared to control mice expressing EGFP alone during retrieval test in the conditioned context 1 day after learning. In contrast, the same optogenetic inhibition of MEC inputs performed 30 min before retrieval test did not affect freezing during retrieval test, excluding the possibility of non-specific deleterious effect of optical inhibition on retrieval process. Same inhibition after auditory fear conditioning, an associative learning that does not require hippocampus activity, long-term memory was also spared. These results support that contextual fear memory formation requires MEC inputs to the hippocampus during a post-learning period. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.title | Entorhinal-hippocampal circuit function in episodic memory consolidation | - |
dc.title.alternative | 일화기억 경화현상의 내비피질-해마 신경회로 기능 연구 | - |
dc.type | Thesis(Ph.D) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :생명과학과, | - |
dc.contributor.alternativeauthor | 강민수 | - |
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