DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Chung, Won-Suk | - |
dc.contributor.advisor | 정원석 | - |
dc.contributor.author | Park, Jungjoo | - |
dc.date.accessioned | 2023-06-22T19:33:17Z | - |
dc.date.available | 2023-06-22T19:33:17Z | - |
dc.date.issued | 2022 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=996333&flag=dissertation | en_US |
dc.identifier.uri | http://hdl.handle.net/10203/308460 | - |
dc.description | 학위논문(박사) - 한국과학기술원 : 생명과학과, 2022.2,[iv, 84 p. :] | - |
dc.description.abstract | Microglia and astrocytes contribute to synapse elimination through phagocytosis during development and neurological disorders. However, the “eat-me” signal that initiates glia-mediated phagocytosis of synapses remains unknown. In this study, I generate neuronal specific Cdc50a knockout mice to induce stable phosphatidylserine exposure in the neuronal outer membrane. Surprisingly, acute Cdc50a deletion in neurons causes specific loss of inhibitory post-synapses without affecting other synapses, thereby generating excessive excitability with audiogenic seizure. Ablating microglia or deleting microglial Mertk rescues the loss of inhibitory post-synapses, indicating that microglial phagocytosis is responsible for inhibitory post-synapse elimination. Moreover, inhibitory post-synapses in normal juvenile brains also use phosphatidylserine for synapse pruning by microglia, suggesting that phosphatidylserine may serve as a general “eat-me” signal for inhibitory post-synapse elimination. | - |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.title | Investigating molecular mechanisms of glia-mediated synapse pruning | - |
dc.title.alternative | 신경교세포에 의한 시냅스 소멸의 분자적 기전 | - |
dc.type | Thesis(Ph.D) | - |
dc.identifier.CNRN | 325007 | - |
dc.description.department | 한국과학기술원 :생명과학과, | - |
dc.contributor.alternativeauthor | 박정주 | - |
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