Investigating molecular mechanisms of glia-mediated synapse pruning신경교세포에 의한 시냅스 소멸의 분자적 기전

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dc.contributor.advisorChung, Won-Suk-
dc.contributor.advisor정원석-
dc.contributor.authorPark, Jungjoo-
dc.date.accessioned2023-06-22T19:33:17Z-
dc.date.available2023-06-22T19:33:17Z-
dc.date.issued2022-
dc.identifier.urihttp://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=996333&flag=dissertationen_US
dc.identifier.urihttp://hdl.handle.net/10203/308460-
dc.description학위논문(박사) - 한국과학기술원 : 생명과학과, 2022.2,[iv, 84 p. :]-
dc.description.abstractMicroglia and astrocytes contribute to synapse elimination through phagocytosis during development and neurological disorders. However, the “eat-me” signal that initiates glia-mediated phagocytosis of synapses remains unknown. In this study, I generate neuronal specific Cdc50a knockout mice to induce stable phosphatidylserine exposure in the neuronal outer membrane. Surprisingly, acute Cdc50a deletion in neurons causes specific loss of inhibitory post-synapses without affecting other synapses, thereby generating excessive excitability with audiogenic seizure. Ablating microglia or deleting microglial Mertk rescues the loss of inhibitory post-synapses, indicating that microglial phagocytosis is responsible for inhibitory post-synapse elimination. Moreover, inhibitory post-synapses in normal juvenile brains also use phosphatidylserine for synapse pruning by microglia, suggesting that phosphatidylserine may serve as a general “eat-me” signal for inhibitory post-synapse elimination.-
dc.languageeng-
dc.publisher한국과학기술원-
dc.titleInvestigating molecular mechanisms of glia-mediated synapse pruning-
dc.title.alternative신경교세포에 의한 시냅스 소멸의 분자적 기전-
dc.typeThesis(Ph.D)-
dc.identifier.CNRN325007-
dc.description.department한국과학기술원 :생명과학과,-
dc.contributor.alternativeauthor박정주-
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