DC Field | Value | Language |
---|---|---|
dc.contributor.author | Qi, Sixian | ko |
dc.contributor.author | Zhong, Zhenxing | ko |
dc.contributor.author | Zhu, Yuwen | ko |
dc.contributor.author | Wang, Yebin | ko |
dc.contributor.author | Ma, Mingyue | ko |
dc.contributor.author | Wang, Yu | ko |
dc.contributor.author | Liu, Xincheng | ko |
dc.contributor.author | Jin, Ruxin | ko |
dc.contributor.author | Jiao, Zhihan | ko |
dc.contributor.author | Zhu, Rui | ko |
dc.contributor.author | Sha, Zhao | ko |
dc.contributor.author | Dang, Kyvan | ko |
dc.contributor.author | Liu, Ying | ko |
dc.contributor.author | Lim, Dae-Sik | ko |
dc.contributor.author | Mao, Junhao | ko |
dc.contributor.author | Zhang, Lei | ko |
dc.contributor.author | Yu, Fa-Xing | ko |
dc.date.accessioned | 2023-06-09T01:00:24Z | - |
dc.date.available | 2023-06-09T01:00:24Z | - |
dc.date.created | 2023-04-03 | - |
dc.date.issued | 2023-06 | - |
dc.identifier.citation | EMBO JOURNAL, v.42, no.11 | - |
dc.identifier.issn | 0261-4189 | - |
dc.identifier.uri | http://hdl.handle.net/10203/307174 | - |
dc.description.abstract | The Hippo pathway is a central regulator of organ size and tumorigenesis and is commonly depicted as a kinase cascade, with an increasing number of regulatory and adaptor proteins linked to its regulation over recent years. Here, we propose that two Hippo signaling modules, MST1/2-SAV1-WWC1-3 (HPO1) and MAP4K1-7-NF2 (HPO2), together regulate the activity of LATS1/2 kinases and YAP/TAZ transcriptional co-activators. In mouse livers, the genetic inactivation of either HPO1 or HPO2 module results in partial activation of YAP/TAZ, bile duct hyperplasia, and hepatocellular carcinoma (HCC). On the contrary, inactivation of both HPO1 and HPO2 modules results in full activation of YAP/TAZ, rapid development of intrahepatic cholangiocarcinoma (iCCA), and early lethality. Interestingly, HPO1 has a predominant role in regulating organ size. HPO1 inactivation causes a homogenous YAP/TAZ activation and cell proliferation across the whole liver, resulting in a proportional and rapid increase in liver size. Thus, this study has reconstructed the order of the Hippo signaling network and suggests that LATS1/2 and YAP/TAZ activities are finetuned by HPO1 and HPO2 modules to cause different cell fates, organ size changes, and tumorigenesis trajectories. | - |
dc.language | English | - |
dc.publisher | WILEY | - |
dc.title | Two Hippo signaling modules orchestrate liver size and tumorigenesis | - |
dc.type | Article | - |
dc.identifier.wosid | 000949240500001 | - |
dc.identifier.scopusid | 2-s2.0-85149961336 | - |
dc.type.rims | ART | - |
dc.citation.volume | 42 | - |
dc.citation.issue | 11 | - |
dc.citation.publicationname | EMBO JOURNAL | - |
dc.identifier.doi | 10.15252/embj.2022112126 | - |
dc.contributor.localauthor | Lim, Dae-Sik | - |
dc.contributor.nonIdAuthor | Qi, Sixian | - |
dc.contributor.nonIdAuthor | Zhong, Zhenxing | - |
dc.contributor.nonIdAuthor | Zhu, Yuwen | - |
dc.contributor.nonIdAuthor | Wang, Yebin | - |
dc.contributor.nonIdAuthor | Ma, Mingyue | - |
dc.contributor.nonIdAuthor | Wang, Yu | - |
dc.contributor.nonIdAuthor | Liu, Xincheng | - |
dc.contributor.nonIdAuthor | Jin, Ruxin | - |
dc.contributor.nonIdAuthor | Jiao, Zhihan | - |
dc.contributor.nonIdAuthor | Zhu, Rui | - |
dc.contributor.nonIdAuthor | Sha, Zhao | - |
dc.contributor.nonIdAuthor | Dang, Kyvan | - |
dc.contributor.nonIdAuthor | Liu, Ying | - |
dc.contributor.nonIdAuthor | Mao, Junhao | - |
dc.contributor.nonIdAuthor | Zhang, Lei | - |
dc.contributor.nonIdAuthor | Yu, Fa-Xing | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Hippo | - |
dc.subject.keywordAuthor | liver cancer | - |
dc.subject.keywordAuthor | NF2 | - |
dc.subject.keywordAuthor | organ size | - |
dc.subject.keywordAuthor | YAP | - |
dc.subject.keywordPlus | CELL-PROLIFERATION | - |
dc.subject.keywordPlus | ORGAN SIZE | - |
dc.subject.keywordPlus | INTRAHEPATIC CHOLANGIOCARCINOMA | - |
dc.subject.keywordPlus | TISSUE HOMEOSTASIS | - |
dc.subject.keywordPlus | GENOMIC ANALYSIS | - |
dc.subject.keywordPlus | YAP ONCOPROTEIN | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | KIBRA | - |
dc.subject.keywordPlus | YAP/TAZ | - |
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