DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jiheon | ko |
dc.contributor.author | Lee, Sanghyeon | ko |
dc.contributor.author | Han, Sunkyu | ko |
dc.contributor.author | Lee, Hee-Yoon | ko |
dc.date.accessioned | 2023-05-13T00:00:15Z | - |
dc.date.available | 2023-05-13T00:00:15Z | - |
dc.date.created | 2023-05-13 | - |
dc.date.created | 2023-05-13 | - |
dc.date.created | 2023-05-13 | - |
dc.date.created | 2023-05-13 | - |
dc.date.issued | 2023-05 | - |
dc.identifier.citation | CHEM, v.9, no.5, pp.1270 - 1280 | - |
dc.identifier.issn | 2451-9294 | - |
dc.identifier.uri | http://hdl.handle.net/10203/306769 | - |
dc.description.abstract | Since the initial discovery of conidiogenone in 2002, over 20 highly congested 6/5/5/5-fused cyclopianes have been isolated and have served as an arena for the development of new synthetic strategies. While the D-ring with distinct oxidative decorations serves as a fingerprint region of these natural products, most synthetic approaches focused on the construction of the highly congested tetracyclic structure, and a divergent synthetic approach amenable to D-ring modifications remains unknown. Herein, we describe a synthetic strategy that enabled a divergent synthesis of six conidiogenones, including three first total syntheses. Trimethylenemethane (TMM) diyl-mediated cycloaddition expediently forged the tetracyclic conidiogenone core. The olefin moiety that was formed as a result of the TMM-based cycloaddition served as a synthetic handle for subsequent stereoselective D-ring diversifications. © 2023 Elsevier Inc. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.title | Divergent synthesis of conidiogenones B–F and 12β-hydroxyconidiogenone C | - |
dc.type | Article | - |
dc.identifier.wosid | 001001357300001 | - |
dc.identifier.scopusid | 2-s2.0-85150302889 | - |
dc.type.rims | ART | - |
dc.citation.volume | 9 | - |
dc.citation.issue | 5 | - |
dc.citation.beginningpage | 1270 | - |
dc.citation.endingpage | 1280 | - |
dc.citation.publicationname | CHEM | - |
dc.identifier.doi | 10.1016/j.chempr.2023.01.018 | - |
dc.contributor.localauthor | Han, Sunkyu | - |
dc.contributor.localauthor | Lee, Hee-Yoon | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | conidiogenones | - |
dc.subject.keywordAuthor | divergent synthesis | - |
dc.subject.keywordAuthor | quaternary carbons | - |
dc.subject.keywordAuthor | SDG3: Good health and well-being | - |
dc.subject.keywordAuthor | tandem cyclizations | - |
dc.subject.keywordAuthor | trimethylenemethane diyl | - |
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