DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kang, Yea Eun | ko |
dc.contributor.author | Kim, Jin-Man | ko |
dc.contributor.author | Kim, Koon Soon | ko |
dc.contributor.author | Chang, Joon Young | ko |
dc.contributor.author | Jung, Mingyu | ko |
dc.contributor.author | Lee, Junguee | ko |
dc.contributor.author | Yi, Shinae | ko |
dc.contributor.author | Kim, Hyeon Woo | ko |
dc.contributor.author | Kim, Jung Tae | ko |
dc.contributor.author | Lee, Kyungmin | ko |
dc.contributor.author | Choi, Min Jeong | ko |
dc.contributor.author | Kang, Seul Ki | ko |
dc.contributor.author | Lee, Seong Eun | ko |
dc.contributor.author | Yi, Hyon-Seung | ko |
dc.contributor.author | Koo, Bon Seok | ko |
dc.contributor.author | Shong, Minho | ko |
dc.date.accessioned | 2023-04-16T01:03:12Z | - |
dc.date.available | 2023-04-16T01:03:12Z | - |
dc.date.created | 2023-04-12 | - |
dc.date.created | 2023-04-12 | - |
dc.date.issued | 2017-12 | - |
dc.identifier.citation | ONCOTARGET, v.8, no.70, pp.114980 - 114994 | - |
dc.identifier.issn | 1949-2553 | - |
dc.identifier.uri | http://hdl.handle.net/10203/306307 | - |
dc.description.abstract | The signaling pathway involving the R-spondins and its cognate receptor, GPR48/LGR4, is crucial in development and carcinogenesis. However, the functional implications of the R-spondin-GPR48/LGR4 pathway in thyroid remain to be identified. The aim of this study was to investigate the role of R-spondin-GPR48/LGR4 signaling in papillary thyroid carcinomas. We retrospectively reviewed a total of 214 patients who underwent total thyroidectomy and cervical lymph node dissection for papillary thyroid carcinoma. The role of GPR48/LGR4 in proliferation and migration was examined in thyroid cancer cell lines. R-spondin 2, and GPR48/LGR4 were expressed at significantly higher levels in thyroid cancer than in normal controls. Elevated GPR48/LGR4 expression was significantly associated with tumor size (P=0.049), lymph node metastasis (P=0.004), recurrence (P=0.037), and the BRAFV600E mutation (P=0.003). Moreover, high GPR48/LGR4 expression was an independent risk factor for lymph node metastasis (P=0.027) and the BRAFV600E mutation (P=0.009). in vitro assays demonstrated that elevated expression of GPR48/LGR4 promoted proliferation and migration of thyroid cancer cells, whereas downregulation of GPR48/LGR4 decreased proliferation and migration by inhibition of the beta-catenin pathway. Moreover, treatment of thyroid cancer cells with exogenous R-spondin 2 induced activation of the beta-catenin pathway through GPR48/LGR4. The R-spondin 2-GPR48/LGR4 signaling axis also induced the phosphorylation of ERK, as well as phosphorylation of LRP6 and serine 9 of GSK3 beta. Our findings demonstrate that upregulation of the R-spondin 2-GPR48/LGR4 pathway contributes to tumor aggressiveness in papillary thyroid carcinoma by promoting ERK phosphorylation, suggesting that this pathway represents a novel therapeutic target for treatment of differentiated thyroid cancer. | - |
dc.language | English | - |
dc.publisher | IMPACT JOURNALS LLC | - |
dc.title | Upregulation of RSPO2-GPR48/LGR4 signaling in papillary thyroid carcinoma contributes to tumor progression | - |
dc.type | Article | - |
dc.identifier.wosid | 000419571000052 | - |
dc.identifier.scopusid | 2-s2.0-85039756160 | - |
dc.type.rims | ART | - |
dc.citation.volume | 8 | - |
dc.citation.issue | 70 | - |
dc.citation.beginningpage | 114980 | - |
dc.citation.endingpage | 114994 | - |
dc.citation.publicationname | ONCOTARGET | - |
dc.identifier.doi | 10.18632/oncotarget.22692 | - |
dc.contributor.localauthor | Shong, Minho | - |
dc.contributor.nonIdAuthor | Kang, Yea Eun | - |
dc.contributor.nonIdAuthor | Kim, Jin-Man | - |
dc.contributor.nonIdAuthor | Kim, Koon Soon | - |
dc.contributor.nonIdAuthor | Chang, Joon Young | - |
dc.contributor.nonIdAuthor | Jung, Mingyu | - |
dc.contributor.nonIdAuthor | Lee, Junguee | - |
dc.contributor.nonIdAuthor | Yi, Shinae | - |
dc.contributor.nonIdAuthor | Kim, Hyeon Woo | - |
dc.contributor.nonIdAuthor | Kim, Jung Tae | - |
dc.contributor.nonIdAuthor | Lee, Kyungmin | - |
dc.contributor.nonIdAuthor | Choi, Min Jeong | - |
dc.contributor.nonIdAuthor | Kang, Seul Ki | - |
dc.contributor.nonIdAuthor | Lee, Seong Eun | - |
dc.contributor.nonIdAuthor | Yi, Hyon-Seung | - |
dc.contributor.nonIdAuthor | Koo, Bon Seok | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | RSPO2 | - |
dc.subject.keywordAuthor | GPR48/LGR4 | - |
dc.subject.keywordAuthor | papillary thyroid carcinoma | - |
dc.subject.keywordAuthor | BRAFV600E mutation | - |
dc.subject.keywordAuthor | beta-catenin pathway | - |
dc.subject.keywordPlus | PROTEIN-COUPLED RECEPTORS | - |
dc.subject.keywordPlus | WNT/BETA-CATENIN | - |
dc.subject.keywordPlus | BETA-CATENIN | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | DOWN-REGULATION | - |
dc.subject.keywordPlus | TYROSINE KINASE | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | LGR5 | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
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