DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Dong Wook | ko |
dc.contributor.author | Hwang, Jung Hwan | ko |
dc.contributor.author | Suh, Jae Mi | ko |
dc.contributor.author | Kim, Ho | ko |
dc.contributor.author | Song, Jung Hun | ko |
dc.contributor.author | Hwang, Eun Suk | ko |
dc.contributor.author | Hwang, Il Young | ko |
dc.contributor.author | Park, Ki Cheol | ko |
dc.contributor.author | Chung, Hyo Kyun | ko |
dc.contributor.author | Kim, Jin Man | ko |
dc.contributor.author | Park, Jongsun | ko |
dc.contributor.author | Hemmings, Brian A | ko |
dc.contributor.author | Shong, Minho | ko |
dc.date.accessioned | 2023-04-13T07:00:27Z | - |
dc.date.available | 2023-04-13T07:00:27Z | - |
dc.date.created | 2023-04-12 | - |
dc.date.created | 2023-04-12 | - |
dc.date.issued | 2003-07 | - |
dc.identifier.citation | MOLECULAR ENDOCRINOLOGY, v.17, no.7, pp.1382 - 1394 | - |
dc.identifier.issn | 0888-8809 | - |
dc.identifier.uri | http://hdl.handle.net/10203/306209 | - |
dc.description.abstract | Thyroid cancers are a leading cause of death due to endocrine malignancies. RET/PTC (rearranged in transformation/papillary thyroid carcinomas) gene rearrangements are the most frequent genetic alterations identified in papillary thyroid carcinoma. Although the oncogenic potential of RET/PTC is related to intrinsic tyrosine kinase activity, the substrates for this enzyme are yet to be identified. In this report, we show that phosphoinositide-dependent kinase 1 (PDK1), a pivotal serine/threonine kinase in growth factor-signaling pathways, is a target of RET/PTC. RET/PTC and PDK1 colocalize in the cytoplasm. RET/PTC phosphorylates a specific tyrosine (Y9) residue located in the N-terminal region of PDK1. Y9 phosphorylation of PDK1 by RET/PTC requires an intact catalytic kinase domain. The short (iso 9) and long forms (iso 51) of the RET/PTC kinases (RET/PTC1 and RET/PTC3) induce Y9 phosphorylation of PDK1. Moreover, Y9 phosphorylation of PDK1 by RET/PTC does not require phosphatidylinositol 3-kinase or Src activity. RET/PTC-induced phosphorylation of the Y9 residue results in increased PDK1 activity, decrease of cellular p53 levels, and repression of p53-dependent transactivation. In conclusion, RET/PTC-induced tyrosine phosphorylation of PDK1 may be one of the mechanisms by which it acts as an oncogenic tyrosine kinase in thyroid carcinogenesis. | - |
dc.language | English | - |
dc.publisher | OXFORD UNIV PRESS INC | - |
dc.title | RET/PTC (rearranged in transformation/papillary thyroid carcinomas) tyrosine kinase phosphorylates and activates phosphoinositide-dependent kinase 1 (PDK1): An alternative phosphatidylinositol 3-kinase-independent pathway to activate PDK1 | - |
dc.type | Article | - |
dc.identifier.wosid | 000183885500016 | - |
dc.identifier.scopusid | 2-s2.0-12444299997 | - |
dc.type.rims | ART | - |
dc.citation.volume | 17 | - |
dc.citation.issue | 7 | - |
dc.citation.beginningpage | 1382 | - |
dc.citation.endingpage | 1394 | - |
dc.citation.publicationname | MOLECULAR ENDOCRINOLOGY | - |
dc.identifier.doi | 10.1210/me.2002-0402 | - |
dc.contributor.localauthor | Shong, Minho | - |
dc.contributor.nonIdAuthor | Kim, Dong Wook | - |
dc.contributor.nonIdAuthor | Hwang, Jung Hwan | - |
dc.contributor.nonIdAuthor | Suh, Jae Mi | - |
dc.contributor.nonIdAuthor | Kim, Ho | - |
dc.contributor.nonIdAuthor | Song, Jung Hun | - |
dc.contributor.nonIdAuthor | Hwang, Eun Suk | - |
dc.contributor.nonIdAuthor | Hwang, Il Young | - |
dc.contributor.nonIdAuthor | Park, Ki Cheol | - |
dc.contributor.nonIdAuthor | Chung, Hyo Kyun | - |
dc.contributor.nonIdAuthor | Kim, Jin Man | - |
dc.contributor.nonIdAuthor | Park, Jongsun | - |
dc.contributor.nonIdAuthor | Hemmings, Brian A | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE-1 | - |
dc.subject.keywordPlus | DOCKING SITE | - |
dc.subject.keywordPlus | RET PROTOONCOGENE | - |
dc.subject.keywordPlus | TRANSFORMING GENE | - |
dc.subject.keywordPlus | SIGNALING PATHWAY | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | 3-KINASE | - |
dc.subject.keywordPlus | ABNORMALITIES | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.