DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hwang, Eun Suk | ko |
dc.contributor.author | Kim, Dong Wook | ko |
dc.contributor.author | Hwang, Jung Hwan | ko |
dc.contributor.author | Jung, Hye Sook | ko |
dc.contributor.author | Suh, Jae Mi | ko |
dc.contributor.author | Park, Young Joo | ko |
dc.contributor.author | Chung, Hyo Kyun | ko |
dc.contributor.author | Song, Jung Hun | ko |
dc.contributor.author | Park, Ki Cheol | ko |
dc.contributor.author | Park, Su Hyeon | ko |
dc.contributor.author | Yun, Hwan Jung | ko |
dc.contributor.author | Kim, Jin Man | ko |
dc.contributor.author | Shong, Minho | ko |
dc.date.accessioned | 2023-04-13T06:00:53Z | - |
dc.date.available | 2023-04-13T06:00:53Z | - |
dc.date.created | 2023-04-12 | - |
dc.date.created | 2023-04-12 | - |
dc.date.issued | 2004-11 | - |
dc.identifier.citation | MOLECULAR ENDOCRINOLOGY, v.18, no.11, pp.2672 - 2684 | - |
dc.identifier.issn | 0888-8809 | - |
dc.identifier.uri | http://hdl.handle.net/10203/306202 | - |
dc.description.abstract | Chimeric RET/PTC (rearranged in transformation/papillary thyroid carcinoma) oncoproteins are constitutively active tyrosine kinases found in thyroid papillary carcinoma and nonneoplastic Hashimoto's thyroiditis. Although several proteins have been identified to be substrates of RET/PTC kinases, the pathogenic roles played by RET/PTC in malignant and benign thyroid diseases and the molecular mechanisms that are involved are not fully understood. We found that RET/PTC expression phosphorylates the Y701 residue of STAT1, a type II interferon (IFN)-responsive protein. RET/PTC-mediated signal transducer and activator of transcription 1 (STAT1) phosphorylation requires RET/PTC kinase activity to be intact but other tyrosine kinases, such as Janus kinases or c-Src, are not involved. RET/PTC-induced STAT1 transcriptional activation was not inhibited by suppressor of cytokine signaling-1 or -3, or protein inhibitors of activated STAT3 [(protein inhibitor of activated STAT (PIAS3)], but PIAS1 strongly repressed the RET/PTC-induced transcriptional activity of STAT1. RET/PTC-induced STAT1 activation caused IFN regulatory factor-1 expression. We found that STAT1 and IFN regulatory factor-1 cooperated to significantly increase transcription from type IV IFN-gamma-responsive promoters of class II transactivator genes. Significantly, cells stably expressing RET/PTC expressed class II transactivator and showed enhanced de novo membrane expression of major histocompatibility complex (MHC) class II proteins. Furthermore, RET/PTC1-bearing papillary thyroid carcinoma cells strongly expressed MHC class II (human leukocyte-associated antigen-DRalpha) genes, whereas the surrounding normal tissues did not. Thus, RET/PTC is able to phosphorylate and activate STAT1. This may lead to enhanced MHC class II expression, which may explain why the tissues surrounding RET/PTC-positive cancers are infiltrated with lymphocytes. Such immune response-promoting activity of RET/PTC may also relate to the development of Hashimoto's thyroiditis. | - |
dc.language | English | - |
dc.publisher | OXFORD UNIV PRESS INC | - |
dc.title | Regulation of signal transducer and activator of transcription 1 (STAT1) and STAT1-dependent genes by RET/PTC (rearranged in transformation/papillary thyroid carcinoma) oncogenic tyrosine kinases | - |
dc.type | Article | - |
dc.identifier.wosid | 000224732600006 | - |
dc.identifier.scopusid | 2-s2.0-8344287016 | - |
dc.type.rims | ART | - |
dc.citation.volume | 18 | - |
dc.citation.issue | 11 | - |
dc.citation.beginningpage | 2672 | - |
dc.citation.endingpage | 2684 | - |
dc.citation.publicationname | MOLECULAR ENDOCRINOLOGY | - |
dc.identifier.doi | 10.1210/me.2004-0168 | - |
dc.contributor.localauthor | Shong, Minho | - |
dc.contributor.nonIdAuthor | Hwang, Eun Suk | - |
dc.contributor.nonIdAuthor | Kim, Dong Wook | - |
dc.contributor.nonIdAuthor | Hwang, Jung Hwan | - |
dc.contributor.nonIdAuthor | Jung, Hye Sook | - |
dc.contributor.nonIdAuthor | Suh, Jae Mi | - |
dc.contributor.nonIdAuthor | Park, Young Joo | - |
dc.contributor.nonIdAuthor | Chung, Hyo Kyun | - |
dc.contributor.nonIdAuthor | Song, Jung Hun | - |
dc.contributor.nonIdAuthor | Park, Ki Cheol | - |
dc.contributor.nonIdAuthor | Park, Su Hyeon | - |
dc.contributor.nonIdAuthor | Yun, Hwan Jung | - |
dc.contributor.nonIdAuthor | Kim, Jin Man | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | RET PROTOONCOGENE | - |
dc.subject.keywordPlus | SH2 DOMAIN | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | ANTIGEN | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | JAK | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | INHIBITOR | - |
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