DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Yun-Yong | ko |
dc.contributor.author | Park, Ki Cheol | ko |
dc.contributor.author | Shong, Minho | ko |
dc.contributor.author | Lee, Soon-Jung | ko |
dc.contributor.author | Lee, Young-Ho | ko |
dc.contributor.author | Choi, Hueng-Sik | ko |
dc.date.accessioned | 2023-04-13T05:00:55Z | - |
dc.date.available | 2023-04-13T05:00:55Z | - |
dc.date.created | 2023-04-12 | - |
dc.date.created | 2023-04-12 | - |
dc.date.issued | 2007-12 | - |
dc.identifier.citation | MOLECULES AND CELLS, v.24, no.3, pp.372 - 377 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.uri | http://hdl.handle.net/10203/306191 | - |
dc.description.abstract | The orphan nuclear receptor, SF-1, plays a pivotal role in the development and differentiation of the endocrine and reproductive systems, and also regulates the transcription of a host of genes, including those encoding several steroidogenic enzymes and gonadotropins. We found that a previously unidentified repressor, EID-1, is an SF-1-interacting protein that inhibits the transactivation of SF-1. A transient transfection assay revealed that EID-1 inhibits SF-1, but not LRH-1, ERR gamma, or mCAR. Using the yeast two hybrid and GST pull-down assays, we determined that EID-1 interacted strongly with SF-1. In addition, it colocalized with SF-1 in mammalian cells and interacted specifically with the AF-2 domain of SF-1, competing with SRC-1 to inhibit SF-1 transactivation. EID-1 is expressed in the mouse testis, and its expression decreases during testis development. The results of the present study suggest that EID-1 can act as a repressor, regulating the function of SF-1. | - |
dc.language | English | - |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | - |
dc.title | EID-1 interacts with orphan nuclear receptor SF-1 and represses its transactovation | - |
dc.type | Article | - |
dc.identifier.wosid | 000252248000010 | - |
dc.type.rims | ART | - |
dc.citation.volume | 24 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 372 | - |
dc.citation.endingpage | 377 | - |
dc.citation.publicationname | MOLECULES AND CELLS | - |
dc.contributor.localauthor | Shong, Minho | - |
dc.contributor.nonIdAuthor | Park, Yun-Yong | - |
dc.contributor.nonIdAuthor | Park, Ki Cheol | - |
dc.contributor.nonIdAuthor | Lee, Soon-Jung | - |
dc.contributor.nonIdAuthor | Lee, Young-Ho | - |
dc.contributor.nonIdAuthor | Choi, Hueng-Sik | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | EID-1 | - |
dc.subject.keywordAuthor | nuclear receptor | - |
dc.subject.keywordAuthor | SF-1 | - |
dc.subject.keywordAuthor | testis | - |
dc.subject.keywordAuthor | transcriptional repression | - |
dc.subject.keywordPlus | SMALL HETERODIMER PARTNER | - |
dc.subject.keywordPlus | STEROIDOGENIC FACTOR-I | - |
dc.subject.keywordPlus | ENDOCRINE DEVELOPMENT | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | DAX-1 | - |
dc.subject.keywordPlus | FACTOR-1 | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | TRANSACTIVATION | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
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