DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jo, Young Suk | ko |
dc.contributor.author | Hwang, Eun Suk | ko |
dc.contributor.author | Lee, Ju Hee | ko |
dc.contributor.author | Lee, Yunhyeong | ko |
dc.contributor.author | Kim, Seul Young | ko |
dc.contributor.author | Choi, Yun-Sun | ko |
dc.contributor.author | Bai, Youn-Sun | ko |
dc.contributor.author | Hong, Jun Hwa | ko |
dc.contributor.author | Kim, Yun-Jeung | ko |
dc.contributor.author | Lee, Ihn-Suk | ko |
dc.contributor.author | Rha, So Young | ko |
dc.contributor.author | Ro, Heung-Kyu | ko |
dc.contributor.author | Shong, Minho | ko |
dc.date.accessioned | 2023-04-13T05:00:42Z | - |
dc.date.available | 2023-04-13T05:00:42Z | - |
dc.date.created | 2023-04-12 | - |
dc.date.created | 2023-04-12 | - |
dc.date.issued | 2008-04 | - |
dc.identifier.citation | JOURNAL OF KOREAN MEDICAL SCIENCE, v.23, no.2, pp.262 - 269 | - |
dc.identifier.issn | 1011-8934 | - |
dc.identifier.uri | http://hdl.handle.net/10203/306188 | - |
dc.description.abstract | Members of the inhibitors of differentiation (Id) family of helix-loop-helix (HLH) proteins are known to play important roles in the proliferation and differentiation of many cell types. Thyroid-stimulating hormone (TSH) regulates proliferation and differentiation by activating TSH receptor (TSHR) in thyrocytes. In this study, we found that Id2, one of the Id family proteins, is a major target for regulation by TSH in FRTL-5 thyroid cells. TSH rapidly increases the Id2 mRNA level in FRTL-5 thyroid cells but the Id2 protein showed biphasic regulatory patterns, being transiently reduced and subsequently induced by TSH treatment. Transient reduction of Id2 protein was noted within 2 hr of TSH treatment and was mediated by proteasomal degradation. Moreover, reduced Id2 expression correlated with the activity of the phosphatidylinositol 3 kinase pathway, which is activated by TSH. Although TSH increases the activity of the Id2 promoter, TSH-induced activation of this promoter was independent of c-Myc. Id2 did not alter TTF-1- and Pax-8-mediated effects on the regulation of the Tg promoter. Thus, in summary, we found that TSH regulates Id2 expression, but that Id2 does not alter the expression of thyroid-specific genes, such as Tg, in FRTL-5 thyroid cells. | - |
dc.language | English | - |
dc.publisher | KOREAN ACAD MEDICAL SCIENCES | - |
dc.title | Regulation of inhibitors of differentiation family proteins by thyroid-stimulating hormone in FRTL-5 thyroid cells | - |
dc.type | Article | - |
dc.identifier.wosid | 000255967500015 | - |
dc.identifier.scopusid | 2-s2.0-43449089821 | - |
dc.type.rims | ART | - |
dc.citation.volume | 23 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 262 | - |
dc.citation.endingpage | 269 | - |
dc.citation.publicationname | JOURNAL OF KOREAN MEDICAL SCIENCE | - |
dc.identifier.doi | 10.3346/jkms.2008.23.2.262 | - |
dc.identifier.kciid | ART001242339 | - |
dc.contributor.localauthor | Shong, Minho | - |
dc.contributor.nonIdAuthor | Jo, Young Suk | - |
dc.contributor.nonIdAuthor | Hwang, Eun Suk | - |
dc.contributor.nonIdAuthor | Lee, Ju Hee | - |
dc.contributor.nonIdAuthor | Lee, Yunhyeong | - |
dc.contributor.nonIdAuthor | Kim, Seul Young | - |
dc.contributor.nonIdAuthor | Choi, Yun-Sun | - |
dc.contributor.nonIdAuthor | Bai, Youn-Sun | - |
dc.contributor.nonIdAuthor | Hong, Jun Hwa | - |
dc.contributor.nonIdAuthor | Kim, Yun-Jeung | - |
dc.contributor.nonIdAuthor | Lee, Ihn-Suk | - |
dc.contributor.nonIdAuthor | Rha, So Young | - |
dc.contributor.nonIdAuthor | Ro, Heung-Kyu | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | thyroid gland | - |
dc.subject.keywordAuthor | thyrotropin | - |
dc.subject.keywordAuthor | Id2 protein | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTOR-I | - |
dc.subject.keywordPlus | PHOSPHATIDYLINOSITOL 3-KINASE | - |
dc.subject.keywordPlus | RETINOBLASTOMA PROTEIN | - |
dc.subject.keywordPlus | NEGATIVE REGULATOR | - |
dc.subject.keywordPlus | DNA-BINDING | - |
dc.subject.keywordPlus | PROTEASOME | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INSULIN | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | ID2 | - |
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