DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Sun-Yee | ko |
dc.contributor.author | Jeoung, Nam Ho | ko |
dc.contributor.author | Oh, Chang Joo | ko |
dc.contributor.author | Choi, Young-Keun | ko |
dc.contributor.author | Lee, Hyo-Jeong | ko |
dc.contributor.author | Kim, Han-Jong | ko |
dc.contributor.author | Kim, Joon-Young | ko |
dc.contributor.author | Hwang, Jung Hwan | ko |
dc.contributor.author | Tadi, Surendar | ko |
dc.contributor.author | Yim, Yong-Hyeon | ko |
dc.contributor.author | Lee, Ki-Up | ko |
dc.contributor.author | Park, Keun-Gyu | ko |
dc.contributor.author | Huh, Seung | ko |
dc.contributor.author | Min, Ki-Nam | ko |
dc.contributor.author | Jeong, Kyeong-Hoon | ko |
dc.contributor.author | Park, Myoung Gyu | ko |
dc.contributor.author | Kwak, Tae Hwan | ko |
dc.contributor.author | Kweon, Gi Ryang | ko |
dc.contributor.author | Inukai, Kouichi | ko |
dc.contributor.author | Shong, Minho | ko |
dc.contributor.author | Lee, In-Kyu | ko |
dc.date.accessioned | 2023-04-12T07:01:33Z | - |
dc.date.available | 2023-04-12T07:01:33Z | - |
dc.date.created | 2023-04-12 | - |
dc.date.created | 2023-04-12 | - |
dc.date.issued | 2009-04 | - |
dc.identifier.citation | CIRCULATION RESEARCH, v.104, no.7, pp.842 - 850 | - |
dc.identifier.issn | 0009-7330 | - |
dc.identifier.uri | http://hdl.handle.net/10203/306177 | - |
dc.description.abstract | Abnormal proliferation and migration of vascular smooth muscle cells (VSMCs) are important pathogenic mechanisms in atherosclerosis and restenosis after vascular injury. In this study, we investigated the effects of beta-lapachone (beta L) (3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione), which is a potent antitumor agent that stimulates NAD(P)H:quinone oxidoreductase (NQO)1 activity, on neointimal formation in animals given vascular injury and on the proliferation of VSMCs cultured in vitro. beta L significantly reduced the neointimal formation induced by balloon injury. beta L also dose-dependently inhibited the FCS- or platelet-derived growth factor-induced proliferation of VSMCs by inhibiting G(1)/S phase transition. beta L increased the phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase 1 in rat and human VSMCs. Chemical inhibitors of AMPK or dominant-negative AMPK blocked the beta L-induced suppression of cell proliferation and the G(1) cell cycle arrest, in vitro and in vivo. The activation of AMPK in VSMCs by beta L is mediated by LKB1 in the presence of NQO1. Taken together, these results show that beta L inhibits VSMCs proliferation via the NQO1 and LKB1-dependent activation of AMPK. These observations provide the molecular basis that pharmacological stimulation of NQO1 activity is a new therapy for the treatment of vascular restenosis and/or atherosclerosis which are caused by proliferation of VSMCs. (Circ Res. 2009;104:842-850.) | - |
dc.language | English | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.title | Activation of NAD(P) H:Quinone Oxidoreductase 1 Prevents Arterial Restenosis by Suppressing Vascular Smooth Muscle Cell Proliferation | - |
dc.type | Article | - |
dc.identifier.wosid | 000265051400005 | - |
dc.identifier.scopusid | 2-s2.0-65249124172 | - |
dc.type.rims | ART | - |
dc.citation.volume | 104 | - |
dc.citation.issue | 7 | - |
dc.citation.beginningpage | 842 | - |
dc.citation.endingpage | 850 | - |
dc.citation.publicationname | CIRCULATION RESEARCH | - |
dc.identifier.doi | 10.1161/CIRCRESAHA.108.189837 | - |
dc.contributor.localauthor | Shong, Minho | - |
dc.contributor.nonIdAuthor | Kim, Sun-Yee | - |
dc.contributor.nonIdAuthor | Jeoung, Nam Ho | - |
dc.contributor.nonIdAuthor | Oh, Chang Joo | - |
dc.contributor.nonIdAuthor | Choi, Young-Keun | - |
dc.contributor.nonIdAuthor | Lee, Hyo-Jeong | - |
dc.contributor.nonIdAuthor | Kim, Han-Jong | - |
dc.contributor.nonIdAuthor | Kim, Joon-Young | - |
dc.contributor.nonIdAuthor | Hwang, Jung Hwan | - |
dc.contributor.nonIdAuthor | Tadi, Surendar | - |
dc.contributor.nonIdAuthor | Yim, Yong-Hyeon | - |
dc.contributor.nonIdAuthor | Lee, Ki-Up | - |
dc.contributor.nonIdAuthor | Park, Keun-Gyu | - |
dc.contributor.nonIdAuthor | Huh, Seung | - |
dc.contributor.nonIdAuthor | Min, Ki-Nam | - |
dc.contributor.nonIdAuthor | Jeong, Kyeong-Hoon | - |
dc.contributor.nonIdAuthor | Park, Myoung Gyu | - |
dc.contributor.nonIdAuthor | Kwak, Tae Hwan | - |
dc.contributor.nonIdAuthor | Kweon, Gi Ryang | - |
dc.contributor.nonIdAuthor | Inukai, Kouichi | - |
dc.contributor.nonIdAuthor | Lee, In-Kyu | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | vascular smooth muscle cell | - |
dc.subject.keywordAuthor | beta-lapachone | - |
dc.subject.keywordAuthor | AMPK | - |
dc.subject.keywordAuthor | NQO1 | - |
dc.subject.keywordAuthor | restenosis | - |
dc.subject.keywordPlus | PROTEIN-KINASE ACTIVITY | - |
dc.subject.keywordPlus | BETA-LAPACHONE | - |
dc.subject.keywordPlus | NEOINTIMA-FORMATION | - |
dc.subject.keywordPlus | CYCLE PROGRESSION | - |
dc.subject.keywordPlus | CANCER CELLS | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | ENERGY | - |
dc.subject.keywordPlus | AMPK | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | EXPRESSION | - |
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