DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kwon, Hyun Joo | ko |
dc.contributor.author | Heo, Jun Young | ko |
dc.contributor.author | Shim, Jung Hee | ko |
dc.contributor.author | Park, Ji Hoon | ko |
dc.contributor.author | Seo, Kang Sik | ko |
dc.contributor.author | Ryu, Min Jeong | ko |
dc.contributor.author | Han, Jeong Su | ko |
dc.contributor.author | Shong, Minho | ko |
dc.contributor.author | Son, Jin H. | ko |
dc.contributor.author | Kweon, Gi Ryang | ko |
dc.date.accessioned | 2023-04-12T07:01:07Z | - |
dc.date.available | 2023-04-12T07:01:07Z | - |
dc.date.created | 2023-04-12 | - |
dc.date.created | 2023-04-12 | - |
dc.date.issued | 2011-04 | - |
dc.identifier.citation | TOXICOLOGY LETTERS, v.202, no.2, pp.85 - 92 | - |
dc.identifier.issn | 0378-4274 | - |
dc.identifier.uri | http://hdl.handle.net/10203/306171 | - |
dc.description.abstract | There are two causes of Parkinson's disease (PD): environmental insults and genetic mutations of PD-associated genes. Environmental insults and genetic mutations lead to mitochondrial dysfunction, and a combination of mitochondrial dysfunction and increased oxidative stress in dopaminergic neurons is thought to contribute to the pathogenesis of PD. Among the PD-associated genes, DJ-1 acts as a redox sensor for oxidative stress and has been also proposed to maintain mitochondrial complex I activity. To understand molecular functions of DJ-1 in the cell, we have generated DJ-1 null cells from the DJ-1(-/-) mouse embryos. Using these null cells, we investigated the susceptibility to an environmental toxin, paraquat, which is known to inhibit mitochondrial complex I. Interestingly, we found that DJ-1 null cells showed a resistance to paraquat-induced apoptosis, including reduced poly (ADP-ribose) polymerase and procaspase-3. Also DJ-1 null cells generated less superoxide than SN4741 cells by paraquat treatment. Consistent with the reduced paraquat sensitivity, DJ-1 null cells showed reduced complex I activity, which was partially rescued by ectopic DJ-I expression. In summary, our results suggest that DJ-1 is critical to maintain mitochondrial complex land complex I could be a key target in interaction of paraquat toxicity and DJ-1 for giving rise to PD. (C) 2011 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.title | DJ-1 mediates paraquat-induced dopaminergic neuronal cell death | - |
dc.type | Article | - |
dc.identifier.wosid | 000289708000002 | - |
dc.identifier.scopusid | 2-s2.0-79952618692 | - |
dc.type.rims | ART | - |
dc.citation.volume | 202 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 85 | - |
dc.citation.endingpage | 92 | - |
dc.citation.publicationname | TOXICOLOGY LETTERS | - |
dc.identifier.doi | 10.1016/j.toxlet.2011.01.018 | - |
dc.contributor.localauthor | Shong, Minho | - |
dc.contributor.nonIdAuthor | Kwon, Hyun Joo | - |
dc.contributor.nonIdAuthor | Heo, Jun Young | - |
dc.contributor.nonIdAuthor | Shim, Jung Hee | - |
dc.contributor.nonIdAuthor | Park, Ji Hoon | - |
dc.contributor.nonIdAuthor | Seo, Kang Sik | - |
dc.contributor.nonIdAuthor | Ryu, Min Jeong | - |
dc.contributor.nonIdAuthor | Han, Jeong Su | - |
dc.contributor.nonIdAuthor | Son, Jin H. | - |
dc.contributor.nonIdAuthor | Kweon, Gi Ryang | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | DJ-1 | - |
dc.subject.keywordAuthor | Paraquat | - |
dc.subject.keywordAuthor | Mitochondrial complex I | - |
dc.subject.keywordAuthor | Parkinson&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordPlus | FAMILIAL PARKINSONS-DISEASE | - |
dc.subject.keywordPlus | NEUROBLASTOMA SH-SY5Y CELLS | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | LINKED GENE DJ-1 | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | COMPLEX-I | - |
dc.subject.keywordPlus | MITOCHONDRIAL LOCALIZATION | - |
dc.subject.keywordPlus | ENVIRONMENTAL TOXINS | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | TOXICITY | - |
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