The indole derivative NecroX-7 improves nonalcoholic steatohepatitis in ob/ob mice through suppression of mitochondrial ROS/RNS and inflammation

Cited 27 time in webofscience Cited 0 time in scopus
  • Hit : 50
  • Download : 0
DC FieldValueLanguage
dc.contributor.authorChung, Hyo Kyunko
dc.contributor.authorKim, Yong Kyungko
dc.contributor.authorPark, Ji-Hoonko
dc.contributor.authorRyu, Min Jeongko
dc.contributor.authorChang, Joon Youngko
dc.contributor.authorHwang, Jung Hwanko
dc.contributor.authorLee, Chul-Hoko
dc.contributor.authorKim, Soon-Hako
dc.contributor.authorKim, Hyun Jinko
dc.contributor.authorKweon, Gi Ryangko
dc.contributor.authorKim, Koon Soonko
dc.contributor.authorShong, Minhoko
dc.date.accessioned2023-04-12T06:01:17Z-
dc.date.available2023-04-12T06:01:17Z-
dc.date.created2023-04-12-
dc.date.created2023-04-12-
dc.date.issued2015-04-
dc.identifier.citationLIVER INTERNATIONAL, v.35, no.4, pp.1341 - 1353-
dc.identifier.issn1478-3223-
dc.identifier.urihttp://hdl.handle.net/10203/306142-
dc.description.abstractBackground & AimsNonalcoholic steatohepatitis (NASH) is associated with cirrhosis and hepatocellular carcinoma. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play key roles in the development of the disease. However, the therapeutic target of NASH has not been fully defined and new treatments are needed. We investigated the protective effects of the antioxidant indole-derived NecroX-7 in a NASH mouse model using leptin-deficient ob/ob and methionine- and choline-deficient (MCD) diet-fed ob/ob mice. MethodsSix-week-old male mice were divided into three groups: ob/+ mice, ob/ob mice treated with vehicle and ob/ob mice treated daily with NecroX-7 (20mg/kg) for 4weeks. To study the effects of NecroX-7 in a fibrosis model, NASH was induced by feeding ob/ob mice an MCD diet. The effects of NecroX-7 on NASH progression were evaluated using biochemical, histological and molecular markers. ResultsNecroX-7-treated ob/ob mice had a marked decrease in serum aspartate aminotransferase and alanine transaminase compared with vehicle-treated controls. Interestingly, hepatic steatosis and lipid peroxidation were significantly improved by NecroX-7 treatment. NecroX-7 inhibited tert-butylhydroperoxide- and H2O2-induced mitochondrial ROS/RNS in primary hepatocytes and attenuated mitochondrial dysfunction in vitro and in vivo. Furthermore, NecroX-7-treated mice exhibited fewer infiltrating macrophages and reduced hepatic tumour necrosis factor-alpha expression. Hepatic fibrosis in MCD-fed ob/ob mice was significantly decreased by NecroX-7 treatment. ConclusionsNecroX-7 treatment improved hepatic steatosis and fibrosis in murine NASH models. These effects occurred through the suppression of whole-cell ROS/RNS and inflammatory responses and suggest that NecroX-7 has a potential therapeutic benefit in steatohepatitis.-
dc.languageEnglish-
dc.publisherWILEY-
dc.titleThe indole derivative NecroX-7 improves nonalcoholic steatohepatitis in ob/ob mice through suppression of mitochondrial ROS/RNS and inflammation-
dc.typeArticle-
dc.identifier.wosid000351151100024-
dc.identifier.scopusid2-s2.0-84924551539-
dc.type.rimsART-
dc.citation.volume35-
dc.citation.issue4-
dc.citation.beginningpage1341-
dc.citation.endingpage1353-
dc.citation.publicationnameLIVER INTERNATIONAL-
dc.identifier.doi10.1111/liv.12741-
dc.contributor.localauthorShong, Minho-
dc.contributor.nonIdAuthorChung, Hyo Kyun-
dc.contributor.nonIdAuthorKim, Yong Kyung-
dc.contributor.nonIdAuthorPark, Ji-Hoon-
dc.contributor.nonIdAuthorRyu, Min Jeong-
dc.contributor.nonIdAuthorChang, Joon Young-
dc.contributor.nonIdAuthorHwang, Jung Hwan-
dc.contributor.nonIdAuthorLee, Chul-Ho-
dc.contributor.nonIdAuthorKim, Soon-Ha-
dc.contributor.nonIdAuthorKim, Hyun Jin-
dc.contributor.nonIdAuthorKweon, Gi Ryang-
dc.contributor.nonIdAuthorKim, Koon Soon-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorantioxidant-
dc.subject.keywordAuthormitochondrial dysfunction-
dc.subject.keywordAuthorNASH-
dc.subject.keywordAuthorNecroX-7-
dc.subject.keywordPlusFATTY LIVER-DISEASE-
dc.subject.keywordPlusOXIDATIVE STRESS-
dc.subject.keywordPlusN-ACETYLCYSTEINE-
dc.subject.keywordPlusINSULIN-RESISTANCE-
dc.subject.keywordPlusHEPATIC STEATOSIS-
dc.subject.keywordPlusLIPID PEROXIDES-
dc.subject.keywordPlusDYSFUNCTION-
dc.subject.keywordPlusPROGRESSION-
dc.subject.keywordPlusFIBROSIS-
dc.subject.keywordPlusASSAY-
Appears in Collection
MSE-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 27 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0