The Role of Growth Differentiation Factor 15 in Energy Metabolism

Cited 15 time in webofscience Cited 0 time in scopus
  • Hit : 75
  • Download : 0
Growth differentiation factor 15 (GDF15) is receiving great interest beyond its role as an aging and disease-related biomarker. Recent discovery of its receptor, glial cell line-derived neurotrophic factor (GDNF) family receptor a-like (GFRAL), suggests a central role in appetite regulation. However, there is also considerable evidence that GDF15 may have peripheral activity through an as-of-yet undiscovered mode of action. This raises the question as to whether increased GDF15 induction during pathophysiologic conditions also suppresses appetite. The present review will briefly introduce the discovery of GDF15 and describe the different contexts under which GDF15 is induced, focusing on its induction during mitochondrial dysfunction. We will further discuss the metabolic role of GDF15 under various pathophysiological conditions and conclude with possible therapeutic applications.
Publisher
KOREAN DIABETES ASSOC
Issue Date
2020-06
Language
English
Article Type
Article
Citation

DIABETES & METABOLISM JOURNAL, v.44, no.3, pp.363 - 371

ISSN
2233-6079
DOI
10.4093/dmj.2020.0087
URI
http://hdl.handle.net/10203/306119
Appears in Collection
MSE-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 15 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0