Orthodenticle homeobox 2 is transported to lysosomes by nuclear budding vesicles

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dc.contributor.authorPark, Jun Wooko
dc.contributor.authorLee, Eun Jungko
dc.contributor.authorMoon, Eunyoungko
dc.contributor.authorKim, Hong-Limko
dc.contributor.authorKim, In-Beomko
dc.contributor.authorHodzic, Didierko
dc.contributor.authorKim, Namsukko
dc.contributor.authorKweon, Hee-Seokko
dc.contributor.authorKim, Jin Wooko
dc.date.accessioned2023-03-27T05:01:22Z-
dc.date.available2023-03-27T05:01:22Z-
dc.date.created2023-03-27-
dc.date.issued2023-02-
dc.identifier.citationNATURE COMMUNICATIONS, v.14, no.1-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/10203/305814-
dc.description.abstractMany homeodomain transcription factors are secreted and move to neighboring cells. Here, orthodenticle homeobox 2 is shown to be exported from the nucleus in a nuclear membrane, which buds off to then be degraded or secreted. Transcription factors (TFs) are transported from the cytoplasm to the nucleus and disappear from the nucleus after they regulate gene expression. Here, we discover an unconventional nuclear export of the TF, orthodenticle homeobox 2 (OTX2), in nuclear budding vesicles, which transport OTX2 to the lysosome. We further find that torsin1a (Tor1a) is responsible for scission of the inner nuclear vesicle, which captures OTX2 using the LINC complex. Consistent with this, in cells expressing an ATPase-inactive Tor1a Delta E mutant and the LINC (linker of nucleoskeleton and cytoskeleton) breaker KASH2, OTX2 accumulated and formed aggregates in the nucleus. Consequently, in the mice expressing Tor1a Delta E and KASH2, OTX2 could not be secreted from the choroid plexus for transfer to the visual cortex, leading to failed development of parvalbumin neurons and reduced visual acuity. Together, our results suggest that unconventional nuclear egress and secretion of OTX2 are necessary not only to induce functional changes in recipient cells but also to prevent aggregation in donor cells.-
dc.languageEnglish-
dc.publisherNATURE PORTFOLIO-
dc.titleOrthodenticle homeobox 2 is transported to lysosomes by nuclear budding vesicles-
dc.typeArticle-
dc.identifier.wosid000942107800016-
dc.identifier.scopusid2-s2.0-85148974476-
dc.type.rimsART-
dc.citation.volume14-
dc.citation.issue1-
dc.citation.publicationnameNATURE COMMUNICATIONS-
dc.identifier.doi10.1038/s41467-023-36697-5-
dc.contributor.localauthorKim, Jin Woo-
dc.contributor.nonIdAuthorMoon, Eunyoung-
dc.contributor.nonIdAuthorKim, Hong-Lim-
dc.contributor.nonIdAuthorKim, In-Beom-
dc.contributor.nonIdAuthorHodzic, Didier-
dc.contributor.nonIdAuthorKweon, Hee-Seok-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordPlusCORTICAL PLASTICITY-
dc.subject.keywordPlusOTX2 HOMEOPROTEIN-
dc.subject.keywordPlusQUALITY-CONTROL-
dc.subject.keywordPlusLINC COMPLEXES-
dc.subject.keywordPlusBINDING-
dc.subject.keywordPlusEXPORT-
dc.subject.keywordPlusADULT-
dc.subject.keywordPlusLOCALIZATION-
dc.subject.keywordPlusINHIBITORS-
dc.subject.keywordPlusSEQUENCE-
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