Wide-Field Three-Dimensional Depth-Invariant Cellular-Resolution Imaging of the Human Retina

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Three-dimensional (3D) cellular-resolution imaging of the living human retina over a large field of view will bring a great impact in clinical ophthalmology, potentially finding new biomarkers for early diagnosis and improving the pathophysiological understanding of ocular diseases. While hardware-based and computational adaptive optics (AO) optical coherence tomography (OCT) have been developed to achieve cellular-resolution retinal imaging, these approaches support limited 3D imaging fields, and their high cost and intrinsic hardware complexity limit their practical utility. Here, this work demonstrates 3D depth-invariant cellular-resolution imaging of the living human retina over a 3 x 3 mm field of view using the first intrinsically phase-stable multi-MHz retinal swept-source OCT and novel computational defocus and aberration correction methods. Single-acquisition imaging of photoreceptor cells, retinal nerve fiber layer, and retinal capillaries is presented across unprecedented imaging fields. By providing wide-field 3D cellular-resolution imaging in the human retina using a standard point-scan architecture routinely used in the clinic, this platform proposes a strategy for expanded utilization of high-resolution retinal imaging in both research and clinical settings.
Publisher
WILEY-V C H VERLAG GMBH
Issue Date
2023-03
Language
English
Article Type
Article
Citation

SMALL, v.19, no.11

ISSN
1613-6810
DOI
10.1002/smll.202203357
URI
http://hdl.handle.net/10203/305788
Appears in Collection
ME-Journal Papers(저널논문)
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