Multilamellar ceramide core-structured microvehicles with substantial skin barrier function recovery

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This study introduces a multilamellar ceramide core-structured microvehicle platform for substantial skin barrier function recovery. Our approach essentially focused on fabricating bacterial cellulose nanofiber (BCNF)-enveloped ceramide-rich lipid microparticles (CerMPs) by solidifying BCNF-armored oil-in-water Pickering emulsions. The oil drops consisted of Ceramide NP (a phytosphingosine backbone N-acylated with a saturated stearic acid) and fatty alcohols (FAs) with a designated stoichiometry. The thin BCNF shell layer completely blocked the growth of ceramide molecular crystals from the CerMPs for a long time. The CerMP cores displayed a multilamellar structure wherein the interlayer distance and lateral packing could be manipulated using FAs with different alkyl chain lengths. The CerMPs remarkably lowered the trans-epidermal water loss while restoring the structural integrity of the epidermis in damaged skin. The results obtained herein highlight that the CerMP system provides a practical methodology for developing various types of skin-friendly formulations that can strengthen the skin barrier function.
Publisher
ROYAL SOC CHEMISTRY
Issue Date
2023-03
Language
English
Article Type
Article
Citation

JOURNAL OF MATERIALS CHEMISTRY B, v.11, no.10, pp.2135 - 2144

ISSN
2050-7518
DOI
10.1039/d2tb02734h
URI
http://hdl.handle.net/10203/305726
Appears in Collection
MS-Journal Papers(저널논문)
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