A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation

Cited 1198 time in webofscience Cited 0 time in scopus
  • Hit : 111
  • Download : 0
DC FieldValueLanguage
dc.contributor.authorClelland, CDko
dc.contributor.authorChoi, Mineeko
dc.contributor.authorRomberg, Cko
dc.contributor.authorClemenson, GDko
dc.contributor.authorFragniere, Ako
dc.contributor.authorTyers, Pko
dc.contributor.authorJessberger, Sko
dc.contributor.authorSaksida, LMko
dc.contributor.authorBarker, RAko
dc.contributor.authorGage, FHko
dc.contributor.authorBussey, TJko
dc.date.accessioned2023-02-06T02:01:15Z-
dc.date.available2023-02-06T02:01:15Z-
dc.date.created2023-02-06-
dc.date.created2023-02-06-
dc.date.issued2009-07-
dc.identifier.citationSCIENCE, v.325, no.5937, pp.210 - 213-
dc.identifier.issn0036-8075-
dc.identifier.urihttp://hdl.handle.net/10203/305036-
dc.description.abstractThe dentate gyrus (DG) of the mammalian hippocampus is hypothesized to mediate pattern separation-the formation of distinct and orthogonal representations of mnemonic information-and also undergoes neurogenesis throughout life. How neurogenesis contributes to hippocampal function is largely unknown. Using adult mice in which hippocampal neurogenesis was ablated, we found specific impairments in spatial discrimination with two behavioral assays: (i) a spatial navigation radial arm maze task and (ii) a spatial, but non-navigable, task in the mouse touch screen. Mice with ablated neurogenesis were impaired when stimuli were presented with little spatial separation, but not when stimuli were more widely separated in space. Thus, newborn neurons may be necessary for normal pattern separation function in the DG of adult mice.-
dc.languageEnglish-
dc.publisherAMER ASSOC ADVANCEMENT SCIENCE-
dc.titleA Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation-
dc.typeArticle-
dc.identifier.wosid000267802000050-
dc.identifier.scopusid2-s2.0-67650450542-
dc.type.rimsART-
dc.citation.volume325-
dc.citation.issue5937-
dc.citation.beginningpage210-
dc.citation.endingpage213-
dc.citation.publicationnameSCIENCE-
dc.identifier.doi10.1126/science.1173215-
dc.contributor.localauthorChoi, Minee-
dc.contributor.nonIdAuthorClelland, CD-
dc.contributor.nonIdAuthorRomberg, C-
dc.contributor.nonIdAuthorClemenson, GD-
dc.contributor.nonIdAuthorFragniere, A-
dc.contributor.nonIdAuthorTyers, P-
dc.contributor.nonIdAuthorJessberger, S-
dc.contributor.nonIdAuthorSaksida, LM-
dc.contributor.nonIdAuthorBarker, RA-
dc.contributor.nonIdAuthorGage, FH-
dc.contributor.nonIdAuthorBussey, TJ-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordPlusDENTATE GYRUS-
dc.subject.keywordPlusMEMORY-
dc.subject.keywordPlusCA3-
dc.subject.keywordPlusMICE-
dc.subject.keywordPlusENSEMBLES-
dc.subject.keywordPlusCELLS-
dc.subject.keywordPlusTASK-
dc.subject.keywordPlusRATS-
dc.subject.keywordPlusBORN-
Appears in Collection
BC-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 1198 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0