DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Minee | ko |
dc.contributor.author | Vernon, J | ko |
dc.contributor.author | Kopach, O | ko |
dc.contributor.author | Mitlett, MS | ko |
dc.contributor.author | Mills, K | ko |
dc.contributor.author | Clayton, PT | ko |
dc.contributor.author | Meert, T | ko |
dc.contributor.author | Wood, JN | ko |
dc.date.accessioned | 2023-02-06T02:01:08Z | - |
dc.date.available | 2023-02-06T02:01:08Z | - |
dc.date.created | 2023-02-06 | - |
dc.date.created | 2023-02-06 | - |
dc.date.issued | 2015-05 | - |
dc.identifier.citation | NEUROSCIENCE LETTERS, v.594, pp.163 - 168 | - |
dc.identifier.issn | 0304-3940 | - |
dc.identifier.uri | http://hdl.handle.net/10203/305034 | - |
dc.description.abstract | Fabry disease is an X-linked lysosomal storage disorder characterised by accumulation of glycosphin-golipids, and accompanied by clinical manifestations, such as cardiac disorders, renal failure, pain and peripheral neuropathy. Globotriaosylsphingosine (lyso-Gb3), a deacylated form of globotriaosylceramide (Gb3), has emerged as a marker of Fabry disease. We investigated the link between Gb3, lyso-Gb3 and pain. Plantar administration of lyso-Gb3 or Gb3 caused mechanical allodynia in healthy mice. In vitro application of 100 nM lyso-Gb3 caused uptake of extracellular calcium in 10% of sensory neurons expressing nociceptor markers, rising to 40% of neurons at 1 mu M, a concentration that may occur in Fabry disease patients. Peak current densities of voltage-dependent Ca2+ channels were substantially enhanced by application of 1 mu M lyso-Gb3. These studies suggest a direct role for lyso-Gb3 in the sensitisation of peripheral nociceptive neurons that may provide an opportunity for therapeutic intervention in the treatment of Fabry disease-associated pain. (C) 2015 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.title | The Fabry disease-associated lipid Lyso-Gb3 enhances voltage-gated calcium currents in sensory neurons and causes pain | - |
dc.type | Article | - |
dc.identifier.wosid | 000353750200031 | - |
dc.identifier.scopusid | 2-s2.0-84939979395 | - |
dc.type.rims | ART | - |
dc.citation.volume | 594 | - |
dc.citation.beginningpage | 163 | - |
dc.citation.endingpage | 168 | - |
dc.citation.publicationname | NEUROSCIENCE LETTERS | - |
dc.identifier.doi | 10.1016/j.neulet.2015.01.084 | - |
dc.contributor.localauthor | Choi, Minee | - |
dc.contributor.nonIdAuthor | Vernon, J | - |
dc.contributor.nonIdAuthor | Kopach, O | - |
dc.contributor.nonIdAuthor | Mitlett, MS | - |
dc.contributor.nonIdAuthor | Mills, K | - |
dc.contributor.nonIdAuthor | Clayton, PT | - |
dc.contributor.nonIdAuthor | Meert, T | - |
dc.contributor.nonIdAuthor | Wood, JN | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Pain | - |
dc.subject.keywordAuthor | Calcium imaging | - |
dc.subject.keywordAuthor | Voltage-dependent Ca2+ channels | - |
dc.subject.keywordAuthor | Fabry disease | - |
dc.subject.keywordAuthor | Dorsal root ganglia | - |
dc.subject.keywordPlus | GLOBOTRIAOSYLCERAMIDE | - |
dc.subject.keywordPlus | PLASMA | - |
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