A simple assessment model to quantifying the dynamic hippocampal neurogenic process in the adult mammalian brain

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Adult hippocampal neurogenesis is a highly dynamic process in which new cells are born, but only some of which survive. Of late it has become clear that these surviving newborn neurons have functional roles, most notably in certain forms of memory. Conventional methods to look at adult neurogenesis are based on the quantification of the number of newly born neurons using a simple cell counting methodology. However, this type of approach fails to capture the dynamic aspects of the neurogenic process, where neural proliferation, death and differentiation take place continuously and simultaneously. In this paper, we propose a simple mathematical approach to better understand the adult neurogenic process in the hippocampus which in turn will allow for a better analysis of this process in disease states and following drug therapies. (c) 2015 Wiley Periodicals, Inc.
Publisher
WILEY
Issue Date
2016-04
Language
English
Article Type
Article
Citation

HIPPOCAMPUS, v.26, no.4, pp.517 - 529

ISSN
1050-9631
DOI
10.1002/hipo.22541
URI
http://hdl.handle.net/10203/305032
Appears in Collection
BC-Journal Papers(저널논문)
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