Obesity enhances antiviral immunity in the genital mucosa through a microbiota-mediated effect on γδ T cells

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dc.contributor.authorPark, Jang Hyunko
dc.contributor.authorKang, Inko
dc.contributor.authorKim, Hyeon Cheolko
dc.contributor.authorLee, Younghoonko
dc.contributor.authorLee, Sung Kiko
dc.contributor.authorLee, Heung Kyuko
dc.date.accessioned2022-12-22T02:01:12Z-
dc.date.available2022-12-22T02:01:12Z-
dc.date.created2022-12-21-
dc.date.created2022-12-21-
dc.date.created2022-12-21-
dc.date.issued2022-11-
dc.identifier.citationCELL REPORTS, v.41, no.6-
dc.identifier.issn2211-1247-
dc.identifier.urihttp://hdl.handle.net/10203/303469-
dc.description.abstractObesity is detrimental to the immune system. It impairs lymphatics, T cell development, and lymphopoiesis; induces dysfunction of antitumor immunity; and also promotes tumor progression. However, direct evidence of the impact of obesity on viral infection is lacking. We report a protective role of obesity against herpes simplex virus 2 infection of the genital mucosa in mice. Although conventional antiviral immunity is comparable between obese mice and lean mice, obesity enhances the cytotoxic subset of γδ T cells. This effect is mediated by L-arginine produced by commensal microbiota in the genital mucosa, which induces “pseudonormoxia” of γδ T cells, resulting in increased natural killer (NK) group 2 D (NKG2D) expression of γδ T cells through the downregulation of hypoxia-inducible factor 1-alpha (HIF1A) by inducing nitric oxide (NO) production, thereby protecting mice from lethal genital herpes. Thus, our work illuminates one mechanism by which obesity-induced compositional changes in the vaginal microbiota can affect mucosal immune responses against viral infection. © 2022 The Authors-
dc.languageEnglish-
dc.publisherCELL PRESS-
dc.titleObesity enhances antiviral immunity in the genital mucosa through a microbiota-mediated effect on γδ T cells-
dc.typeArticle-
dc.identifier.wosid000922749000004-
dc.identifier.scopusid2-s2.0-85141448317-
dc.type.rimsART-
dc.citation.volume41-
dc.citation.issue6-
dc.citation.publicationnameCELL REPORTS-
dc.identifier.doi10.1016/j.celrep.2022.111594-
dc.contributor.localauthorLee, Younghoon-
dc.contributor.localauthorLee, Heung Kyu-
dc.contributor.nonIdAuthorLee, Sung Ki-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorCP: Immunology-
dc.subject.keywordAuthorCP: Microbiology-
dc.subject.keywordAuthorgenital mucosa-
dc.subject.keywordAuthorHSV-2-
dc.subject.keywordAuthorL-arginine-
dc.subject.keywordAuthorobesity-
dc.subject.keywordAuthorviral infection-
dc.subject.keywordAuthorγδ T cells-
dc.subject.keywordPlusGUT MICROBIOTA-
dc.subject.keywordPlusHERPES-
dc.subject.keywordPlusMICROENVIRONMENT-
dc.subject.keywordPlusTRANSLOCATION-
dc.subject.keywordPlusCONTRIBUTES-
dc.subject.keywordPlusINFECTION-
dc.subject.keywordPlusHYPOXIA-
dc.subject.keywordPlusLESIONS-
dc.subject.keywordPlusMICE-
dc.subject.keywordPlusFAT-
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CH-Journal Papers(저널논문)MSE-Journal Papers(저널논문)
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