Protease inhibitors derived from guamerin구마린에서 유래된 프로테아제 억제제

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The present invention relates to peptides inhibiting elastase and subtilisin activity, which are derived from Guamerin, an elastase-inhibiting protein isolated from a Korean leech, Guameri(Hirudo nipponia). Since the peptides of the invention permit their convenient synthesis and use, it can be applied for the development of elastase- and subtilisin-inhibiting agents. Also, since the dimeric peptides of the invention have strong elastase- and subtilisin-inhibiting activities, they can be more practically applied for the treatment of diseases associated with elastase and subtilisin. Moreover, all of the peptides of the invention can be safely used for human body as a potential drug, since they have relatively lower molecular weights.
Assignee
KAIST
Country
US (United States)
Application Date
1998-05-07
Application Number
09068624
Registration Date
2001-02-06
Registration Number
06184346
URI
http://hdl.handle.net/10203/302871
Appears in Collection
RIMS Patents
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