DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤지민 | ko |
dc.contributor.author | 이민석 | ko |
dc.contributor.author | Ali, Ahsan A | ko |
dc.contributor.author | 오예림 | ko |
dc.contributor.author | 최용석 | ko |
dc.contributor.author | 김수진 | ko |
dc.contributor.author | 이남석 | ko |
dc.contributor.author | 장세광 | ko |
dc.contributor.author | 곽승기 | ko |
dc.contributor.author | 현준영 | ko |
dc.contributor.author | 차승희 | ko |
dc.contributor.author | 이윤종 | ko |
dc.contributor.author | 임성갑 | ko |
dc.contributor.author | 김유식 | ko |
dc.date.accessioned | 2022-12-06T07:07:59Z | - |
dc.date.available | 2022-12-06T07:07:59Z | - |
dc.date.created | 2022-11-28 | - |
dc.date.issued | 2022-06-20 | - |
dc.identifier.citation | 2022 한국분자세포생물학회 리보핵산분과 Summer Symposium | - |
dc.identifier.uri | http://hdl.handle.net/10203/301789 | - |
dc.description.abstract | Sjӧgren’s syndrome (SS) is a systemic autoimmune disease that targets the exocrine glands, resulting in impaired saliva and tear secretion. To date, type I interferons (IFNs) are increasingly recognized as pivotal mediators in SS, but their endogenous drivers have not been elucidated. Here, we investigate the role of mitochondrial double-stranded RNAs (mt-dsRNAs) in regulating type I IFN response in SS. We find that mt-dsRNAs are elevated in the saliva and tear of SS patients as well as in salivary glands of non-obese diabetic mice with salivary dysfunction. In line with this, elevated expressions of mt-dsRNAs are associated with exocrine dysfunction and glandular lymphocytic infiltration from SS patients. Using the in-house-developed 3D culture, we show that dsRNA stimulation increases mt-dsRNAs expression via JAK1/STAT pathway and facilitates their cytosolic export, which is accompanied by autoimmune signatures observed in SS. We further show that muscarinic receptor ligand acetylcholine ameliorates autoimmune characteristics by preventing mt-dsRNA-mediated antiviral signaling. Lastly, we find that hindering mt-dsRNA induction or direct suppression of mt-dsRNA expression via treatment of 2-C′-methyladenosine (2-CM), an inhibitor of mitochondrial RNA polymerase (POLRMT), reverses the autoimmune signatures of SS. Altogether, our study underscores the significance of mt-dsRNA upregulation in exacerbating aberrant immune activation driving autoimmune diseases such as SS. | - |
dc.language | Korean | - |
dc.publisher | 한국분자세포생물학회 | - |
dc.title | Targeting mitochondrial double-stranded RNAs ameliorates autoimmune characteristics of Sjogren’s syndrome | - |
dc.type | Conference | - |
dc.type.rims | CONF | - |
dc.citation.publicationname | 2022 한국분자세포생물학회 리보핵산분과 Summer Symposium | - |
dc.identifier.conferencecountry | KO | - |
dc.identifier.conferencelocation | 부산 해운대 한화리조트 | - |
dc.contributor.localauthor | 임성갑 | - |
dc.contributor.localauthor | 김유식 | - |
dc.contributor.nonIdAuthor | 이민석 | - |
dc.contributor.nonIdAuthor | Ali, Ahsan A | - |
dc.contributor.nonIdAuthor | 오예림 | - |
dc.contributor.nonIdAuthor | 최용석 | - |
dc.contributor.nonIdAuthor | 김수진 | - |
dc.contributor.nonIdAuthor | 이남석 | - |
dc.contributor.nonIdAuthor | 장세광 | - |
dc.contributor.nonIdAuthor | 곽승기 | - |
dc.contributor.nonIdAuthor | 현준영 | - |
dc.contributor.nonIdAuthor | 차승희 | - |
dc.contributor.nonIdAuthor | 이윤종 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.