Data on the evaluation of the relation between β-arrestin 2 and YAP phosphorylation in patient-derived colon cancer organoids

Abstract

The data presented in this article is related to a rapid com-munication entitled "fi-arrestin 2 suppresses the activation of YAP by promoting LATS kinase activity". This article de-scribes the correlation of fi-arrestin 2 and YAP phospho-rylation in patient-derived organoid models. Here, we ana-lyzed 45 colon cancer organoids (CCOs) selected in the re-lated research article to investigate the role of fi-arrestin 2 in YAP phosphorylation. Hematoxylin and eosin (H&E) staining and immunohistochemistry data showed that the CCOs main-tained tissue architecture and histological features of their original cancer tissues. Moreover, mutation data detected from RNA-seq (RNA-sequencing) analysis showed that these CCOs retained the genetic features of their original colon can-cer tissues as well. We also confirmed at the protein level that organoids expressing fi-arrestin 2 showed high expres-sion of phosphorylated YAP. These organoid model studies strongly support the related research article that ,B-arrestin 2 suppresses the activation of YAP in colon cancer.(c) 2022 Published by Elsevier Inc. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ )