This paper confirms the difference in structure manufacturing cost and behavior due to the change of the column when the frame structure is designed based on the plastic design. It is important to select an appropriate column member for a structure that is subjected to both axial and lateral loads. If the plastic design method is adopted to design the structure as efficiently as possible, the role of the column becomes more prominent because it not only serves as the beam but also the column through the connection part to transfer the surplus moment to other members when the beam is subjected to an extreme load or more. In particular, the lateral load requires the ductility of the column, and the CFT-type column member secures the ductility through a higher steel ratio than the RC member. By designing the structure by applying the plastic design to the structure subjected to lateral load, this paper will show that the CFT column member has better performance than the RC column member.