DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Changha | ko |
dc.contributor.author | Jeong, Jinwook | ko |
dc.contributor.author | Vellakkaran, Mari | ko |
dc.contributor.author | Hong, Sungwoo | ko |
dc.date.accessioned | 2022-11-07T05:00:35Z | - |
dc.date.available | 2022-11-07T05:00:35Z | - |
dc.date.created | 2022-11-02 | - |
dc.date.created | 2022-11-02 | - |
dc.date.created | 2022-11-02 | - |
dc.date.created | 2022-11-02 | - |
dc.date.created | 2022-11-02 | - |
dc.date.created | 2022-11-02 | - |
dc.date.created | 2022-11-02 | - |
dc.date.created | 2022-11-02 | - |
dc.date.issued | 2022-10 | - |
dc.identifier.citation | ACS CATALYSIS, v.12, no.21, pp.13225 - 13233 | - |
dc.identifier.issn | 2155-5435 | - |
dc.identifier.uri | http://hdl.handle.net/10203/299341 | - |
dc.description.abstract | Site-selective C-H functionalization of heteroarenes is important for the rapid modification of bioactive molecules. Herein, we report an efficient photocatalytic platform for the visible-light-mediated C-H alkylation of pyridines at the C4 position using alkyl carboxylic acids as alkylating agents under external oxidant-free conditions. Importantly, the released N-centered radical can serve as an effective oxidizing agent for single-electron transfer (SET) oxidation to efficiently regenerate the photocatalyst. This photocatalytic system is appealing from a mechanistic perspective and is amenable to a broad substrate scope for carboxylic acids and pyridines containing oxidatively sensitive functionalities that do not hold up to other procedures. The strategy offers a practical approach for the C4-selective pyridylation of a diverse range of primary, secondary, and tertiary carboxylic acids and amino acids with various functional groups under mild, metal-free conditions. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Photocatalytic Decarboxylative Pyridylation of Carboxylic Acids Using In Situ-Generated Amidyl Radicals as Oxidants | - |
dc.type | Article | - |
dc.identifier.wosid | 000873801500001 | - |
dc.identifier.scopusid | 2-s2.0-85140314685 | - |
dc.type.rims | ART | - |
dc.citation.volume | 12 | - |
dc.citation.issue | 21 | - |
dc.citation.beginningpage | 13225 | - |
dc.citation.endingpage | 13233 | - |
dc.citation.publicationname | ACS CATALYSIS | - |
dc.identifier.doi | 10.1021/acscatal.2c04417 | - |
dc.contributor.localauthor | Hong, Sungwoo | - |
dc.contributor.nonIdAuthor | Jeong, Jinwook | - |
dc.contributor.nonIdAuthor | Vellakkaran, Mari | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | heterocycles | - |
dc.subject.keywordAuthor | photocatalysis | - |
dc.subject.keywordAuthor | carboxylic acid | - |
dc.subject.keywordAuthor | amidyl radical | - |
dc.subject.keywordAuthor | C-H functionalization | - |
dc.subject.keywordPlus | C-H ALKYLATION | - |
dc.subject.keywordPlus | PHOTOREDOX CATALYSIS | - |
dc.subject.keywordPlus | CENTERED RADICALS | - |
dc.subject.keywordPlus | AMINO-ACIDS | - |
dc.subject.keywordPlus | LIGHT | - |
dc.subject.keywordPlus | PRECURSORS | - |
dc.subject.keywordPlus | HETEROARYLATION | - |
dc.subject.keywordPlus | HETEROARENES | - |
dc.subject.keywordPlus | HETEROCYCLES | - |
dc.subject.keywordPlus | DERIVATIVES | - |
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