DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hyun-Jin | ko |
dc.contributor.author | Park, Jang Hyun | ko |
dc.contributor.author | Kim, Hyeon Cheol | ko |
dc.contributor.author | Kim, Chae Won | ko |
dc.contributor.author | Kang, In | ko |
dc.contributor.author | Lee, Heung Kyu | ko |
dc.date.accessioned | 2022-11-02T06:01:09Z | - |
dc.date.available | 2022-11-02T06:01:09Z | - |
dc.date.created | 2022-11-01 | - |
dc.date.created | 2022-11-01 | - |
dc.date.issued | 2022-10 | - |
dc.identifier.citation | NATURE COMMUNICATIONS, v.13, no.1 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/10203/299243 | - |
dc.description.abstract | Tumor-associated macrophages are believed to promote tumour progression and to hamper immune therapy in gliomas. Here authors identify a distinct population of macrophages within the glioblastoma immune microenvironment with antitumour properties and clearly distinguishable phenotypes and gene expression patterns from tumour promoting macrophages. Infiltrating tumor-associated macrophages (TAM) are known to impede immunotherapy against glioblastoma (GBM), however, TAMs are heterogeneous, and there are no clear markers to distinguish immunosuppressive and potentially immune-activating populations. Here we identify a subset of CD169(+) macrophages promoting an anti-tumoral microenvironment in GBM. Using single-cell transcriptome analysis, we find that CD169(+) macrophages in human and mouse gliomas produce pro-inflammatory chemokines, leading to the accumulation of T cells and NK cells. CD169 expression on macrophages facilitates phagocytosis of apoptotic glioma cells and hence tumor-specific T cell responses. Depletion of CD169(+) macrophages leads to functionally impaired antitumor lymphocytes and poorer survival of glioma-bearing mice. We show that NK-cell-derived IFN-gamma is critical for the accumulation of blood monocyte-derived CD169(+) macrophages in gliomas. Our work thus identifies a well-distinguished TAM subset promoting antitumor immunity against GBM, and identifies key factors that might shift the balance from immunosuppressive to anti-tumor TAM. | - |
dc.language | English | - |
dc.publisher | NATURE PORTFOLIO | - |
dc.title | Blood monocyte-derived CD169(+) macrophages contribute to antitumor immunity against glioblastoma | - |
dc.type | Article | - |
dc.identifier.wosid | 000870821400009 | - |
dc.identifier.scopusid | 2-s2.0-85140219851 | - |
dc.type.rims | ART | - |
dc.citation.volume | 13 | - |
dc.citation.issue | 1 | - |
dc.citation.publicationname | NATURE COMMUNICATIONS | - |
dc.identifier.doi | 10.1038/s41467-022-34001-5 | - |
dc.contributor.localauthor | Lee, Heung Kyu | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | MARGINAL ZONE | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | STIMULATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MICROGLIA | - |
dc.subject.keywordPlus | RESPONSES | - |
dc.subject.keywordPlus | FRONT | - |
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