(A) physiologically based pharmacokinetic model for absorption and distribution of imatinib mesylate in a human body인체 내에서 Imatinib mesylate 흡수와 분포에 관한 생리학적 약물동력학 모델의 연구

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dc.contributor.advisorChowdhury, M.-
dc.contributor.advisorKom, Do-Hyun-
dc.contributor.advisorLee, Tai-Yong-
dc.contributor.advisor김도현-
dc.contributor.advisor이태용-
dc.contributor.authorChowdhury, Muhammad Mahfuz-
dc.contributor.author쵸드리, 무하마드 마푸즈-
dc.date.accessioned2011-12-13T01:55:22Z-
dc.date.available2011-12-13T01:55:22Z-
dc.date.issued2007-
dc.identifier.urihttp://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=264271&flag=dissertation-
dc.identifier.urihttp://hdl.handle.net/10203/29921-
dc.description학위논문(석사) - 한국과학기술원 : 생명화학공학과, 2007.2, [ v, 66 p. ]-
dc.description.abstractA whole body physiologically based pharmacokinetic model is applied to investigate absorption and distribution and the impact of physiologic conditions variation on pharmacokinetic of imatinib mesylate. The model has simulated previously published pharmacokinetic data of the drug in case of intravenous (i.v.) dose and oral dose. Oral dose absorption kinetics has been modeled by adopting Advanced Compartmental Absorption and Transit (ACAT) model in gut section. Tissue:plasma partition coefficients of drug in i.v. dose case are also used in oral dose case. Sensitivity analysis of the whole body PBPK model is done by taking parameters that are commonly subject to variation among human. Adipose tissue drug concentration has been found high compared to other tissues concentration and it act as storage organ for the drug. Variation in metabolism in liver, body weight, and blood:plasma partition coefficient are found to be important factors affecting plasma concentration profile in human body.eng
dc.languageeng-
dc.publisher한국과학기술원-
dc.subjectdrug absorption-
dc.subjectsimulation-
dc.subject약물동력학-
dc.subject약물 흡수-
dc.subject분포-
dc.subject모델링-
dc.subjectPharmacokinetic model-
dc.subjectimatinib-
dc.title(A) physiologically based pharmacokinetic model for absorption and distribution of imatinib mesylate in a human body-
dc.title.alternative인체 내에서 Imatinib mesylate 흡수와 분포에 관한 생리학적 약물동력학 모델의 연구-
dc.typeThesis(Master)-
dc.identifier.CNRN264271/325007 -
dc.description.department한국과학기술원 : 생명화학공학과, -
dc.identifier.uid020054305-
dc.contributor.localauthorChowdhury, M.-
dc.contributor.localauthorKom, Do-Hyun-
dc.contributor.localauthorLee, Tai-Yong-
dc.contributor.localauthor김도현-
dc.contributor.localauthor이태용-
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