Cell-cell interfaces as specialized compartments directing cell function

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Various physiological processes including development and maintenance of epithelia, cell-cell fusion, neuronal function and immune responses rely on the establishment of direct cell-cell contacts. Despite their diversity, the different cell-cell interfaces can be viewed as specialized compartments that perform their distinct functions through common biophysical properties.,Cell-cell interfaces are found throughout multicellular organisms, from transient interactions between motile immune cells to long-lived cell-cell contacts in epithelia. Studies of immune cell interactions, epithelial cell barriers, neuronal contacts and sites of cell-cell fusion have identified a core set of features shared by cell-cell interfaces that critically control their function. Data from diverse cell types also show that cells actively and passively regulate the localization, strength, duration and cytoskeletal coupling of receptor interactions governing cell-cell signalling and physical connections between cells, indicating that cell-cell interfaces have a unique membrane organization that emerges from local molecular and cellular mechanics. In this Review, we discuss recent findings that support the emerging view of cell-cell interfaces as specialized compartments that biophysically constrain the arrangement and activity of their protein, lipid and glycan components. We also review how these biophysical features of cell-cell interfaces allow cells to respond with high selectivity and sensitivity to multiple inputs, serving as the basis for wide-ranging cellular functions. Finally, we consider how the unique properties of cell-cell interfaces present opportunities for therapeutic intervention.,
Publisher
NATURE RESEARCH
Issue Date
2020-12
Language
English
Article Type
Review
Citation

NATURE REVIEWS MOLECULAR CELL BIOLOGY, v.21, no.12, pp.750 - 764

ISSN
1471-0072
DOI
10.1038/s41580-020-00298-7
URI
http://hdl.handle.net/10203/299173
Appears in Collection
BiS-Journal Papers(저널논문)
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