DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Yong Joon | ko |
dc.contributor.author | Kim, Jee Ye | ko |
dc.contributor.author | Jeon, Seung Hyuck | ko |
dc.contributor.author | Nam, Heejin | ko |
dc.contributor.author | Jung, Jae Hyung | ko |
dc.contributor.author | Jeon, Minwoo | ko |
dc.contributor.author | Kim, Eui-Soon | ko |
dc.contributor.author | Bae, Soong June | ko |
dc.contributor.author | Ahn, Juneyoung | ko |
dc.contributor.author | Yoo, Tae-Kyung | ko |
dc.contributor.author | Sun, Woo Young | ko |
dc.contributor.author | Ahn, Sung Gwe | ko |
dc.contributor.author | Jeong, Joon | ko |
dc.contributor.author | Park, Su-Hyung | ko |
dc.contributor.author | Park, Woo Chan | ko |
dc.contributor.author | Kim, Seung Il | ko |
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.date.accessioned | 2022-10-10T03:02:10Z | - |
dc.date.available | 2022-10-10T03:02:10Z | - |
dc.date.created | 2022-10-10 | - |
dc.date.created | 2022-10-10 | - |
dc.date.created | 2022-10-10 | - |
dc.date.issued | 2022-08 | - |
dc.identifier.citation | SCIENCE IMMUNOLOGY, v.7, no.74, pp.eabn8390 | - |
dc.identifier.issn | 2470-9468 | - |
dc.identifier.uri | http://hdl.handle.net/10203/298912 | - |
dc.description.abstract | Despite being a standard treatment option in breast cancer, immune checkpoint inhibitors (ICIs) are only efficacious for a subset of patients. To gain a better understanding of the antitumor immune response in breast cancer, we examined the heterogeneity of CD8(+) T cells in tumors, metastatic lymph nodes (mLNs), and peripheral blood from patients with early breast cancer (n = 131). Among tissue-resident memory CD8(+) T (T-RM) cells, including virus- and tumor-specific CD8(+) T cells, CD39 expression was observed in a tumor-specific and exhausted subpopulation in both tumors and mLNs. CD39(+) T-RM cells from tumors and mLNs exhibited a phenotypic similarity and clonally overlapped with each other. Moreover, tumor or mLN CD39(+) T-RM cells clonally overlapped with CD39(-) T-RM and non-T-R(M) cells in the same compartment, implying a tissue-specific differentiation process. These inter-subpopulationally overlapping CD39(+) T-RM clonotypes were frequently detected among effector memory CD8(+) T cells in peripheral blood, suggesting a systemic clonal overlap. CD39(+) T-RM cell enrichment was heterogeneous among molecular subtypes of breast cancer, which is associated with the different role of antitumor immune responses in each subtype. In vitro blockade of PD-1 and/or CTLA-4 effectively restored proliferation of CD39(+) T-RM cells and enhanced cytokine production by CD8(+) T cells from tumors or mLNs, particularly in the presence of CD39(+) T-RM enrichment. This suggests that CD39(+) T-RM cells have a capacity for functional restoration upon ICI treatment. Thus, our study indicates that CD39(+) T-RM cells with a clonal overlap across compartments are key players in antitumor immunity in breast cancer. | - |
dc.language | English | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.title | CD39(+) tissue-resident memory CD8(+) T cells with a clonal overlap across compartments mediate antitumor immunity in breast cancer | - |
dc.type | Article | - |
dc.identifier.wosid | 000859047400001 | - |
dc.identifier.scopusid | 2-s2.0-85137125397 | - |
dc.type.rims | ART | - |
dc.citation.volume | 7 | - |
dc.citation.issue | 74 | - |
dc.citation.beginningpage | eabn8390 | - |
dc.citation.publicationname | SCIENCE IMMUNOLOGY | - |
dc.identifier.doi | 10.1126/sciimmunol.abn8390 | - |
dc.contributor.localauthor | Park, Su-Hyung | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.nonIdAuthor | Kim, Jee Ye | - |
dc.contributor.nonIdAuthor | Nam, Heejin | - |
dc.contributor.nonIdAuthor | Bae, Soong June | - |
dc.contributor.nonIdAuthor | Ahn, Juneyoung | - |
dc.contributor.nonIdAuthor | Yoo, Tae-Kyung | - |
dc.contributor.nonIdAuthor | Sun, Woo Young | - |
dc.contributor.nonIdAuthor | Ahn, Sung Gwe | - |
dc.contributor.nonIdAuthor | Jeong, Joon | - |
dc.contributor.nonIdAuthor | Park, Woo Chan | - |
dc.contributor.nonIdAuthor | Kim, Seung Il | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | TUMOR-INFILTRATING LYMPHOCYTES | - |
dc.subject.keywordPlus | CD103 | - |
dc.subject.keywordPlus | IMMUNOTHERAPY | - |
dc.subject.keywordPlus | EXHAUSTION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MAGNITUDE | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | SUBSETS | - |
dc.subject.keywordPlus | REVEALS | - |
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