Condensin I associates with structural and gene regulatory regions in vertebrate chromosomes

Cited 53 time in webofscience Cited 0 time in scopus
  • Hit : 204
  • Download : 0
DC FieldValueLanguage
dc.contributor.authorKim, Ji Hunko
dc.contributor.authorZhang, Taoko
dc.contributor.authorWong, Nicholas C.ko
dc.contributor.authorDavidson, Nadiako
dc.contributor.authorMaksimovic, Jovanako
dc.contributor.authorOshlack, Aliciako
dc.contributor.authorEarnshaw, William C.ko
dc.contributor.authorKalitsis, Paulko
dc.contributor.authorHudson, Damien F.ko
dc.date.accessioned2022-09-15T02:00:27Z-
dc.date.available2022-09-15T02:00:27Z-
dc.date.created2022-09-15-
dc.date.created2022-09-15-
dc.date.issued2013-10-
dc.identifier.citationNATURE COMMUNICATIONS, v.4-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/10203/298545-
dc.description.abstractThe condensin complex is essential for correct packaging and segregation of chromosomes during mitosis and meiosis in all eukaryotes. To date, the genome-wide location and the nature of condensin-binding sites have remained elusive in vertebrates. Here we report the genome-wide map of condensin I in chicken DT40 cells. Unexpectedly, we find that condensin I binds predominantly to promoter sequences in mitotic cells. We also find a striking enrichment at both centromeres and telomeres, highlighting the importance of the complex in chromosome segregation. Taken together, the results show that condensin I is largely absent from heterochromatic regions. This map of the condensin I binding sites on the chicken genome reveals that patterns of condensin distribution on chromosomes are conserved from prokaryotes, through yeasts to vertebrates. Thus in three kingdoms of life, condensin is enriched on promoters of actively transcribed genes and at loci important for chromosome segregation.-
dc.languageEnglish-
dc.publisherNATURE PUBLISHING GROUP-
dc.titleCondensin I associates with structural and gene regulatory regions in vertebrate chromosomes-
dc.typeArticle-
dc.identifier.wosid000326468200001-
dc.identifier.scopusid2-s2.0-84885135720-
dc.type.rimsART-
dc.citation.volume4-
dc.citation.publicationnameNATURE COMMUNICATIONS-
dc.identifier.doi10.1038/ncomms3537-
dc.contributor.localauthorKim, Ji Hun-
dc.contributor.nonIdAuthorZhang, Tao-
dc.contributor.nonIdAuthorWong, Nicholas C.-
dc.contributor.nonIdAuthorDavidson, Nadia-
dc.contributor.nonIdAuthorMaksimovic, Jovana-
dc.contributor.nonIdAuthorOshlack, Alicia-
dc.contributor.nonIdAuthorEarnshaw, William C.-
dc.contributor.nonIdAuthorKalitsis, Paul-
dc.contributor.nonIdAuthorHudson, Damien F.-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordPlusTRANSFER-RNA GENES-
dc.subject.keywordPlusMITOTIC CHROMOSOMES-
dc.subject.keywordPlusSMC PROTEINS-
dc.subject.keywordPlusMETAPHASE CHROMOSOMES-
dc.subject.keywordPlusBIOCONDUCTOR PACKAGE-
dc.subject.keywordPlusYEAST CHROMOSOMES-
dc.subject.keywordPlusSEQUENCE-
dc.subject.keywordPlusGENOME-
dc.subject.keywordPlusCENTROMERES-
dc.subject.keywordPlusALIGNMENT-
Appears in Collection
MSE-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 53 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0