DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, Sungmin | ko |
dc.contributor.author | Jung, Jae Hyung | ko |
dc.contributor.author | Noh, Ji Yun | ko |
dc.contributor.author | Kim, Woo-Joon | ko |
dc.contributor.author | Yoon, Soo-Young | ko |
dc.contributor.author | Jung, Jongtak | ko |
dc.contributor.author | Kim, Eu Suk | ko |
dc.contributor.author | Kim, Hong Bin | ko |
dc.contributor.author | Cheong, Hee Jin | ko |
dc.contributor.author | Kim, Woo Joo | ko |
dc.contributor.author | Park, Su-Hyung | ko |
dc.contributor.author | Song, Kyoung-Ho | ko |
dc.contributor.author | Song, Joon Young | ko |
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.date.accessioned | 2022-09-06T01:01:06Z | - |
dc.date.available | 2022-09-06T01:01:06Z | - |
dc.date.created | 2022-09-06 | - |
dc.date.created | 2022-09-06 | - |
dc.date.created | 2022-09-06 | - |
dc.date.created | 2022-09-06 | - |
dc.date.issued | 2022-07 | - |
dc.identifier.citation | CELL REPORTS, v.40, no.4 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | http://hdl.handle.net/10203/298349 | - |
dc.description.abstract | COVID-19 vaccines elicit humoral and cellular immune responses. Durable maintenance of vaccine-induced immunity is required for long-term protection of the host. Here, we examine activation and differentiation of vaccine-induced CD8(+) T cells using MHC class I (MHC-I) multimers and correlations between early differen-tiation and the durability of CD8(+) T cell responses among healthcare workers immunized with two doses of BNT162b2. The frequency of MHC-I multimer(+) cells is robustly increased by BNT162b2 but decreases 6 months post-second vaccination to 2.4%-65.6% (23.0% on average) of the peak. MHC-I multimer(+) cells dominantly exhibit phenotypes of activated effector cells 1-2 weeks post-second vaccination and gradually acquire phenotypes of long-term memory cells, including stem cell-like memory T (TSCM) cells. Importantly, the frequency of T-SCM cells 1-2 weeks post-second vaccination significantly correlates with the 6-month durability of CD8(+) T cells, indicating that early generation of TSCM cells determines the longevity of vac-cine-induced memory CD8(+) T cell responses. | - |
dc.language | English | - |
dc.publisher | CELL PRESS | - |
dc.title | The generation of stem cell-like memory cells early after BNT162b2 vaccination is associated with durability of memory CD8(+) T cell responses | - |
dc.type | Article | - |
dc.identifier.wosid | 000842366700003 | - |
dc.identifier.scopusid | 2-s2.0-85134588870 | - |
dc.type.rims | ART | - |
dc.citation.volume | 40 | - |
dc.citation.issue | 4 | - |
dc.citation.publicationname | CELL REPORTS | - |
dc.identifier.doi | 10.1016/j.celrep.2022.111138 | - |
dc.contributor.localauthor | Park, Su-Hyung | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.nonIdAuthor | Noh, Ji Yun | - |
dc.contributor.nonIdAuthor | Kim, Woo-Joon | - |
dc.contributor.nonIdAuthor | Yoon, Soo-Young | - |
dc.contributor.nonIdAuthor | Jung, Jongtak | - |
dc.contributor.nonIdAuthor | Kim, Eu Suk | - |
dc.contributor.nonIdAuthor | Kim, Hong Bin | - |
dc.contributor.nonIdAuthor | Cheong, Hee Jin | - |
dc.contributor.nonIdAuthor | Kim, Woo Joo | - |
dc.contributor.nonIdAuthor | Song, Kyoung-Ho | - |
dc.contributor.nonIdAuthor | Song, Joon Young | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | CD8+ T cell | - |
dc.subject.keywordAuthor | COVID-19 | - |
dc.subject.keywordAuthor | CP: Immunology | - |
dc.subject.keywordAuthor | memory cell | - |
dc.subject.keywordAuthor | MHC class I multimer | - |
dc.subject.keywordAuthor | SARS-CoV-2 | - |
dc.subject.keywordAuthor | vaccine | - |
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