The generation of stem cell-like memory cells early after BNT162b2 vaccination is associated with durability of memory CD8(+) T cell responses

Cited 6 time in webofscience Cited 0 time in scopus
  • Hit : 340
  • Download : 0
DC FieldValueLanguage
dc.contributor.authorJung, Sungminko
dc.contributor.authorJung, Jae Hyungko
dc.contributor.authorNoh, Ji Yunko
dc.contributor.authorKim, Woo-Joonko
dc.contributor.authorYoon, Soo-Youngko
dc.contributor.authorJung, Jongtakko
dc.contributor.authorKim, Eu Sukko
dc.contributor.authorKim, Hong Binko
dc.contributor.authorCheong, Hee Jinko
dc.contributor.authorKim, Woo Jooko
dc.contributor.authorPark, Su-Hyungko
dc.contributor.authorSong, Kyoung-Hoko
dc.contributor.authorSong, Joon Youngko
dc.contributor.authorShin, Eui-Cheolko
dc.identifier.citationCELL REPORTS, v.40, no.4-
dc.description.abstractCOVID-19 vaccines elicit humoral and cellular immune responses. Durable maintenance of vaccine-induced immunity is required for long-term protection of the host. Here, we examine activation and differentiation of vaccine-induced CD8(+) T cells using MHC class I (MHC-I) multimers and correlations between early differen-tiation and the durability of CD8(+) T cell responses among healthcare workers immunized with two doses of BNT162b2. The frequency of MHC-I multimer(+) cells is robustly increased by BNT162b2 but decreases 6 months post-second vaccination to 2.4%-65.6% (23.0% on average) of the peak. MHC-I multimer(+) cells dominantly exhibit phenotypes of activated effector cells 1-2 weeks post-second vaccination and gradually acquire phenotypes of long-term memory cells, including stem cell-like memory T (TSCM) cells. Importantly, the frequency of T-SCM cells 1-2 weeks post-second vaccination significantly correlates with the 6-month durability of CD8(+) T cells, indicating that early generation of TSCM cells determines the longevity of vac-cine-induced memory CD8(+) T cell responses.-
dc.publisherCELL PRESS-
dc.titleThe generation of stem cell-like memory cells early after BNT162b2 vaccination is associated with durability of memory CD8(+) T cell responses-
dc.citation.publicationnameCELL REPORTS-
dc.contributor.localauthorPark, Su-Hyung-
dc.contributor.localauthorShin, Eui-Cheol-
dc.contributor.nonIdAuthorNoh, Ji Yun-
dc.contributor.nonIdAuthorKim, Woo-Joon-
dc.contributor.nonIdAuthorYoon, Soo-Young-
dc.contributor.nonIdAuthorJung, Jongtak-
dc.contributor.nonIdAuthorKim, Eu Suk-
dc.contributor.nonIdAuthorKim, Hong Bin-
dc.contributor.nonIdAuthorCheong, Hee Jin-
dc.contributor.nonIdAuthorKim, Woo Joo-
dc.contributor.nonIdAuthorSong, Kyoung-Ho-
dc.contributor.nonIdAuthorSong, Joon Young-
dc.subject.keywordAuthorCD8+ T cell-
dc.subject.keywordAuthorCP: Immunology-
dc.subject.keywordAuthormemory cell-
dc.subject.keywordAuthorMHC class I multimer-
Appears in Collection
MSE-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 6 items in WoS Click to see citing articles in records_button


  • mendeley


rss_1.0 rss_2.0 atom_1.0