Conformational and functional changes of the native neuropeptide somatostatin occur in the presence of copper and amyloid-beta

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The progression of neurodegenerative disorders can lead to impaired neurotransmission; however, the role of pathogenic factors associated with these diseases and their impact on the structures and functions of neurotransmitters have not been clearly established. Here we report the discovery that conformational and functional changes of a native neuropeptide, somatostatin (SST), occur in the presence of copper ions, metal-free amyloid-beta (A beta) and metal-bound A beta (metal-A beta) found as pathological factors in the brains of patients with Alzheimer's disease. These pathological elements induce the self-assembly of SST and, consequently, prevent it from binding to the receptor. In the reverse direction, SST notably modifies the aggregation profiles of AD species in the presence of metal ions, attenuating their cytotoxicity and interactions with cell membranes. Our work demonstrates a loss of normal function of SST as a neurotransmitter and a gain of its modulative function against metal-A beta under pathological conditions.
Publisher
NATURE PORTFOLIO
Issue Date
2022-09
Language
English
Article Type
Article
Citation

NATURE CHEMISTRY, v.14, no.9, pp.1021 - 1030

ISSN
1755-4330
DOI
10.1038/s41557-022-00984-3
URI
http://hdl.handle.net/10203/298193
Appears in Collection
CH-Journal Papers(저널논문)BS-Journal Papers(저널논문)
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