DC Field | Value | Language |
---|---|---|
dc.contributor.author | Son, Sungmin | ko |
dc.contributor.author | Grover, William H. | ko |
dc.contributor.author | Burg, Thomas P. | ko |
dc.contributor.author | Manalis, Scott R. | ko |
dc.date.accessioned | 2022-08-09T02:01:18Z | - |
dc.date.available | 2022-08-09T02:01:18Z | - |
dc.date.created | 2022-08-09 | - |
dc.date.created | 2022-08-09 | - |
dc.date.issued | 2008-06 | - |
dc.identifier.citation | ANALYTICAL CHEMISTRY, v.80, no.12, pp.4757 - 4760 | - |
dc.identifier.issn | 0003-2700 | - |
dc.identifier.uri | http://hdl.handle.net/10203/297882 | - |
dc.description.abstract | Universal detectors that maintain high sensitivity as the detection volume is reduced to the subnanoliter scale can enhance the utility of miniaturized total analysis systems (mu-TAS). Here the unique scaling properties of the suspended microchannel resonator (SMR) are exploited to show universal detection in a 10 pL analysis volume with a density detection limit of similar to 1 mu g/cm(3) (10 Hz bandwidth) and a dynamic range of 6 decades. Analytes with low UV extinction coefficients such as polyethylene glycol (PEG) 8 kDa, glucose, and glycine are measured with molar detection limits of 0.66, 13.5, and 31.6 mu M, respectively. To demonstrate the potential for real-time monitoring, gel filtration chromatography was used to separate different molecular weights of PEG as the SMR acquired a chromatogram by measuring the eluate density. This work suggests that the SMR could offer a simple and sensitive universal detector for various separation systems from liquid chromatography to capillary electrophoresis. Moreover, since the SMR is itself a microfluidic channel, it can be directly integrated into mu-TAS without compromising overall performance. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Suspended microchannel resonators for ultralow volume universal detection | - |
dc.type | Article | - |
dc.identifier.wosid | 000256763400039 | - |
dc.identifier.scopusid | 2-s2.0-45249094295 | - |
dc.type.rims | ART | - |
dc.citation.volume | 80 | - |
dc.citation.issue | 12 | - |
dc.citation.beginningpage | 4757 | - |
dc.citation.endingpage | 4760 | - |
dc.citation.publicationname | ANALYTICAL CHEMISTRY | - |
dc.identifier.doi | 10.1021/ac800307a | - |
dc.contributor.localauthor | Son, Sungmin | - |
dc.contributor.nonIdAuthor | Grover, William H. | - |
dc.contributor.nonIdAuthor | Burg, Thomas P. | - |
dc.contributor.nonIdAuthor | Manalis, Scott R. | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | PERFORMANCE LIQUID-CHROMATOGRAPHY | - |
dc.subject.keywordPlus | LIGHT-SCATTERING DETECTION | - |
dc.subject.keywordPlus | REFRACTIVE-INDEX DETECTION | - |
dc.subject.keywordPlus | CAPILLARY-ELECTROPHORESIS | - |
dc.subject.keywordPlus | DENSITY | - |
dc.subject.keywordPlus | INTERFEROMETRY | - |
dc.subject.keywordPlus | COLUMN | - |
dc.subject.keywordPlus | SENSOR | - |
dc.subject.keywordPlus | FLUID | - |
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