TAZ links exercise to mitochondrial biogenesis via mitochondrial transcription factor A

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dc.contributor.authorHwang, Jun-Hako
dc.contributor.authorKim, Kyung Minko
dc.contributor.authorOh, Ho Taekko
dc.contributor.authorYoo, Gi Donko
dc.contributor.authorJeong, Mi Gyeongko
dc.contributor.authorLee, Hyunko
dc.contributor.authorPark, Jooriko
dc.contributor.authorJeong, Kwonko
dc.contributor.authorKim, Yoon Kiko
dc.contributor.authorKo, Young-Gyuko
dc.contributor.authorHwang, Eun Sookko
dc.contributor.authorHong, Jeong-Hoko
dc.date.accessioned2022-08-04T06:00:15Z-
dc.date.available2022-08-04T06:00:15Z-
dc.date.created2022-08-04-
dc.date.created2022-08-04-
dc.date.issued2022-02-
dc.identifier.citationNATURE COMMUNICATIONS, v.13, no.1-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/10203/297755-
dc.description.abstractMitochondria are energy-generating organelles and mitochondrial biogenesis is stimulated to meet energy requirements in response to extracellular stimuli, including exercise. However, the mechanisms underlying mitochondrial biogenesis remain unknown. Here, we demonstrate that transcriptional coactivator with PDZ-binding motif (TAZ) stimulates mitochondrial biogenesis in skeletal muscle. In muscle-specific TAZ-knockout (mKO) mice, mitochondrial biogenesis, respiratory metabolism, and exercise ability were decreased compared to wild-type mice. Mechanistically, TAZ stimulates the translation of mitochondrial transcription factor A via Ras homolog enriched in brain (Rheb)/Rheb like 1 (Rhebl1)-mTOR axis. TAZ stimulates Rhebl1 expression via TEA domain family transcription factor. Rhebl1 introduction by adeno-associated virus or mTOR activation recovered mitochondrial biogenesis in mKO muscle. Physiologically, mKO mice did not stimulate exercise-induced mitochondrial biogenesis. Collectively, our results suggested that TAZ is a novel stimulator for mitochondrial biogenesis and exercise-induced muscle adaptation. Mitochondrial biogenesis is stimulated to meet energy requirements in response to extracellular signals including exercise. TAZ is revealed as a novel stimulator for mitochondrial biogenesis and facilitates exercise-induced muscle adaptation.-
dc.languageEnglish-
dc.publisherNATURE PORTFOLIO-
dc.titleTAZ links exercise to mitochondrial biogenesis via mitochondrial transcription factor A-
dc.typeArticle-
dc.identifier.wosid000752207900006-
dc.identifier.scopusid2-s2.0-85124060958-
dc.type.rimsART-
dc.citation.volume13-
dc.citation.issue1-
dc.citation.publicationnameNATURE COMMUNICATIONS-
dc.identifier.doi10.1038/s41467-022-28247-2-
dc.contributor.localauthorKim, Yoon Ki-
dc.contributor.nonIdAuthorHwang, Jun-Ha-
dc.contributor.nonIdAuthorKim, Kyung Min-
dc.contributor.nonIdAuthorOh, Ho Taek-
dc.contributor.nonIdAuthorYoo, Gi Don-
dc.contributor.nonIdAuthorJeong, Mi Gyeong-
dc.contributor.nonIdAuthorLee, Hyun-
dc.contributor.nonIdAuthorPark, Joori-
dc.contributor.nonIdAuthorJeong, Kwon-
dc.contributor.nonIdAuthorKo, Young-Gyu-
dc.contributor.nonIdAuthorHwang, Eun Sook-
dc.contributor.nonIdAuthorHong, Jeong-Ho-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordPlusSKELETAL-MUSCLE-
dc.subject.keywordPlusHIPPO PATHWAY-
dc.subject.keywordPlusADAPTATIONS-
dc.subject.keywordPlusMETABOLISM-
dc.subject.keywordPlusTRANSDUCTION-
dc.subject.keywordPlusBIOLOGY-
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