DC Field | Value | Language |
---|---|---|
dc.contributor.author | Pan, Q | ko |
dc.contributor.author | Saltzman, AL | ko |
dc.contributor.author | Kim, Yoon Ki | ko |
dc.contributor.author | Misquitta, C | ko |
dc.contributor.author | Shai, O | ko |
dc.contributor.author | Maquat, LE | ko |
dc.contributor.author | Frey, BJ | ko |
dc.contributor.author | Blencowe, BJ | ko |
dc.date.accessioned | 2022-08-04T05:01:11Z | - |
dc.date.available | 2022-08-04T05:01:11Z | - |
dc.date.created | 2022-08-04 | - |
dc.date.created | 2022-08-04 | - |
dc.date.issued | 2006-01 | - |
dc.identifier.citation | GENES & DEVELOPMENT, v.20, no.2, pp.153 - 158 | - |
dc.identifier.issn | 0890-9369 | - |
dc.identifier.uri | http://hdl.handle.net/10203/297751 | - |
dc.description.abstract | Sequence-based analyses have predicted that similar to 35% of mammalian alternative splicing (AS) events produce premature termination codon (PTC)-containing splice variants that are targeted by the process of nonsense-mediated mRNA decay (NMD). This led to speculation that AS may often regulate gene expression by activating NMD. Using AS microarrays, we show that PTC-containing splice variants are generally produced at uniformly low levels across diverse mammalian cells and tissues, independently of the action of NMD. Our results suggest that most PTC-introducing AS events are not under positive selection pressure and therefore may not contribute important functional roles. | - |
dc.language | English | - |
dc.publisher | COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT | - |
dc.title | Quantitative microarray profiling provides evidence against widespread coupling of alternative splicing with nonsense-mediated mRNA decay to control gene expression | - |
dc.type | Article | - |
dc.identifier.wosid | 000234737500005 | - |
dc.identifier.scopusid | 2-s2.0-30944449484 | - |
dc.type.rims | ART | - |
dc.citation.volume | 20 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 153 | - |
dc.citation.endingpage | 158 | - |
dc.citation.publicationname | GENES & DEVELOPMENT | - |
dc.identifier.doi | 10.1101/gad.1382806 | - |
dc.contributor.localauthor | Kim, Yoon Ki | - |
dc.contributor.nonIdAuthor | Pan, Q | - |
dc.contributor.nonIdAuthor | Saltzman, AL | - |
dc.contributor.nonIdAuthor | Misquitta, C | - |
dc.contributor.nonIdAuthor | Shai, O | - |
dc.contributor.nonIdAuthor | Maquat, LE | - |
dc.contributor.nonIdAuthor | Frey, BJ | - |
dc.contributor.nonIdAuthor | Blencowe, BJ | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | alternative splicing | - |
dc.subject.keywordAuthor | microarray analysis | - |
dc.subject.keywordAuthor | nonsense-mediated mRNA decay | - |
dc.subject.keywordAuthor | premature termination codon | - |
dc.subject.keywordPlus | MAMMALIAN-CELLS | - |
dc.subject.keywordPlus | SURVEILLANCE | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | EVENTS | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | TRANSCRIPTS | - |
dc.subject.keywordPlus | MECHANISMS | - |
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