LC3B is an RNA-binding protein to trigger rapid mRNA degradation during autophagy

Cited 42 time in webofscience Cited 0 time in scopus
  • Hit : 636
  • Download : 0
DC FieldValueLanguage
dc.contributor.authorHwang, Hyun Jungko
dc.contributor.authorHa, Hongseokko
dc.contributor.authorLee, Ban Seokko
dc.contributor.authorKim, Bong Heonko
dc.contributor.authorSong, Hyun Kyuko
dc.contributor.authorKim, Yoon Kiko
dc.date.accessioned2022-08-04T05:00:11Z-
dc.date.available2022-08-04T05:00:11Z-
dc.date.created2022-08-04-
dc.date.created2022-08-04-
dc.date.created2022-08-04-
dc.date.created2022-08-04-
dc.date.issued2022-03-
dc.identifier.citationNATURE COMMUNICATIONS, v.13, no.1-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/10203/297736-
dc.description.abstractLC3/ATG8 plays an essential role in autophagy. Here the authors show that LC3B exhibits RNA-binding ability and induces rapid degradation of target mRNAs via autophagic activation, highlighting the interplay between autophagy and RNA biology. LC3/ATG8 has long been appreciated to play a central role in autophagy, by which a variety of cytoplasmic materials are delivered to lysosomes and eventually degraded. However, information on the molecular functions of LC3 in RNA biology is very limited. Here, we show that LC3B is an RNA-binding protein that directly binds to mRNAs with a preference for a consensus AAUAAA motif corresponding to a polyadenylation sequence. Autophagic activation promotes an association between LC3B and target mRNAs and triggers rapid degradation of target mRNAs in a CCR4-NOT-dependent manner before autolysosome formation. Furthermore, our transcriptome-wide analysis reveals that PRMT1 mRNA, which encodes a negative regulator of autophagy, is one of the major substrates. Rapid degradation of PRMT1 mRNA by LC3B facilitates autophagy. Collectively, we demonstrate that LC3B acts as an RNA-binding protein and an mRNA decay factor necessary for efficient autophagy.-
dc.languageEnglish-
dc.publisherNATURE PORTFOLIO-
dc.titleLC3B is an RNA-binding protein to trigger rapid mRNA degradation during autophagy-
dc.typeArticle-
dc.identifier.wosid000770426200004-
dc.identifier.scopusid2-s2.0-85126538927-
dc.type.rimsART-
dc.citation.volume13-
dc.citation.issue1-
dc.citation.publicationnameNATURE COMMUNICATIONS-
dc.identifier.doi10.1038/s41467-022-29139-1-
dc.contributor.localauthorKim, Yoon Ki-
dc.contributor.nonIdAuthorHwang, Hyun Jung-
dc.contributor.nonIdAuthorHa, Hongseok-
dc.contributor.nonIdAuthorLee, Ban Seok-
dc.contributor.nonIdAuthorKim, Bong Heon-
dc.contributor.nonIdAuthorSong, Hyun Kyu-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordPlusMICROTUBULE-ASSOCIATED PROTEIN-1-
dc.subject.keywordPlusLIGHT-CHAIN 3-
dc.subject.keywordPlusIDENTIFICATION-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusREVEALS-
dc.subject.keywordPlusTRANSLATION-
dc.subject.keywordPlusMECHANISM-
dc.subject.keywordPlusCOMPLEX-
Appears in Collection
BS-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 42 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0