Dendritic Cell-Based Immunotherapy in Hot and Cold Tumors

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Dendritic cells mediate innate and adaptive immune responses and are directly involved in the activation of cytotoxic T lymphocytes that kill tumor cells. Dendritic cell-based cancer immunotherapy has clinical benefits. Dendritic cell subsets are diverse, and tumors can be hot or cold, depending on their immunogenicity; this heterogeneity affects the success of dendritic cell-based immunotherapy. Here, we review the ontogeny of dendritic cells and dendritic cell subsets. We also review the characteristics of hot and cold tumors and briefly introduce therapeutic trials related to hot and cold tumors. Lastly, we discuss dendritic cell-based cancer immunotherapy in hot and cold tumors.
Publisher
MDPI
Issue Date
2022-07
Language
English
Article Type
Review
Citation

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.23, no.13

ISSN
1661-6596
DOI
10.3390/ijms23137325
URI
http://hdl.handle.net/10203/297391
Appears in Collection
MSE-Journal Papers(저널논문)
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