DC Field | Value | Language |
---|---|---|
dc.contributor.author | Suo, Chenqu | ko |
dc.contributor.author | Dann, Emma | ko |
dc.contributor.author | Goh, Issac | ko |
dc.contributor.author | Jardine, Laura | ko |
dc.contributor.author | Kleshchevnikov, Vitalii | ko |
dc.contributor.author | Park, Jong-Eun | ko |
dc.contributor.author | Botting, Rachel A. | ko |
dc.contributor.author | Stephenson, Emily | ko |
dc.contributor.author | Engelbert, Justin | ko |
dc.contributor.author | Tuong, Zewen Kelvin | ko |
dc.contributor.author | Polanski, Krzysztof | ko |
dc.contributor.author | Yayon, Nadav | ko |
dc.contributor.author | Xu, Chuan | ko |
dc.contributor.author | Suchanek, Ondrej | ko |
dc.contributor.author | Elmentaite, Rasa | ko |
dc.contributor.author | Conde, Cecilia Dominguez | ko |
dc.contributor.author | He, Peng | ko |
dc.contributor.author | Pritchard, Sophie | ko |
dc.contributor.author | Miah, Mohi | ko |
dc.contributor.author | Moldovan, Corina | ko |
dc.contributor.author | Steemers, Alexander S. | ko |
dc.contributor.author | Mazin, Pavel | ko |
dc.contributor.author | Prete, Martin | ko |
dc.contributor.author | Horsfall, Dave | ko |
dc.contributor.author | Marioni, John C. | ko |
dc.contributor.author | Clatworthy, Menna R. | ko |
dc.contributor.author | Haniffa, Muzlifah | ko |
dc.contributor.author | Teichmann, Sarah A. | ko |
dc.date.accessioned | 2022-07-11T09:01:49Z | - |
dc.date.available | 2022-07-11T09:01:49Z | - |
dc.date.created | 2022-07-11 | - |
dc.date.created | 2022-07-11 | - |
dc.date.created | 2022-07-11 | - |
dc.date.issued | 2022-06 | - |
dc.identifier.citation | SCIENCE, v.376, no.6597, pp.1069 - + | - |
dc.identifier.issn | 0036-8075 | - |
dc.identifier.uri | http://hdl.handle.net/10203/297328 | - |
dc.description.abstract | Single-cell genomics studies have decoded the immune cell composition of several human prenatal organs but were limited in describing the developing immune system as a distributed network across tissues. We profiled nine prenatal tissues combining single-cell RNA sequencing, antigen-receptor sequencing, and spatial transcriptomics to reconstruct the developing human immune system. This revealed the late acquisition of immune-effector functions by myeloid and lymphoid cell subsets and the maturation of monocytes and T cells before peripheral tissue seeding. Moreover, we uncovered system-wide blood and immune cell development beyond primary hematopoietic organs, characterized human prenatal B1 cells, and shed light on the origin of unconventional T cells. Our atlas provides both valuable data resources and biological insights that will facilitate cell engineering, regenerative medicine, and disease understanding. | - |
dc.language | English | - |
dc.publisher | AMER ASSOC ADVANCEMENT SCIENCE | - |
dc.title | Mapping the developing human immune system across organs | - |
dc.type | Article | - |
dc.identifier.wosid | 000806053500038 | - |
dc.identifier.scopusid | 2-s2.0-85131249437 | - |
dc.type.rims | ART | - |
dc.citation.volume | 376 | - |
dc.citation.issue | 6597 | - |
dc.citation.beginningpage | 1069 | - |
dc.citation.endingpage | + | - |
dc.citation.publicationname | SCIENCE | - |
dc.identifier.doi | 10.1126/science.abo0510 | - |
dc.contributor.localauthor | Park, Jong-Eun | - |
dc.contributor.nonIdAuthor | Suo, Chenqu | - |
dc.contributor.nonIdAuthor | Dann, Emma | - |
dc.contributor.nonIdAuthor | Goh, Issac | - |
dc.contributor.nonIdAuthor | Jardine, Laura | - |
dc.contributor.nonIdAuthor | Kleshchevnikov, Vitalii | - |
dc.contributor.nonIdAuthor | Botting, Rachel A. | - |
dc.contributor.nonIdAuthor | Stephenson, Emily | - |
dc.contributor.nonIdAuthor | Engelbert, Justin | - |
dc.contributor.nonIdAuthor | Tuong, Zewen Kelvin | - |
dc.contributor.nonIdAuthor | Polanski, Krzysztof | - |
dc.contributor.nonIdAuthor | Yayon, Nadav | - |
dc.contributor.nonIdAuthor | Xu, Chuan | - |
dc.contributor.nonIdAuthor | Suchanek, Ondrej | - |
dc.contributor.nonIdAuthor | Elmentaite, Rasa | - |
dc.contributor.nonIdAuthor | Conde, Cecilia Dominguez | - |
dc.contributor.nonIdAuthor | He, Peng | - |
dc.contributor.nonIdAuthor | Pritchard, Sophie | - |
dc.contributor.nonIdAuthor | Miah, Mohi | - |
dc.contributor.nonIdAuthor | Moldovan, Corina | - |
dc.contributor.nonIdAuthor | Steemers, Alexander S. | - |
dc.contributor.nonIdAuthor | Mazin, Pavel | - |
dc.contributor.nonIdAuthor | Prete, Martin | - |
dc.contributor.nonIdAuthor | Horsfall, Dave | - |
dc.contributor.nonIdAuthor | Marioni, John C. | - |
dc.contributor.nonIdAuthor | Clatworthy, Menna R. | - |
dc.contributor.nonIdAuthor | Haniffa, Muzlifah | - |
dc.contributor.nonIdAuthor | Teichmann, Sarah A. | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | B-CELL DEVELOPMENT | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | CHEMOKINE | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | THYMUS | - |
dc.subject.keywordPlus | B-1A | - |
dc.subject.keywordPlus | PHENOTYPE | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | REVEALS | - |
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