DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ju, Jaewon | ko |
dc.contributor.author | Jin, Subin | ko |
dc.contributor.author | Kim, Sumin | ko |
dc.contributor.author | Choi, Jae Hyuk | ko |
dc.contributor.author | Lee, Haesung A. | ko |
dc.contributor.author | Son, Donghee | ko |
dc.contributor.author | Lee, Haeshin | ko |
dc.contributor.author | Shin, Mikyung | ko |
dc.date.accessioned | 2022-06-28T01:00:29Z | - |
dc.date.available | 2022-06-28T01:00:29Z | - |
dc.date.created | 2022-06-27 | - |
dc.date.created | 2022-06-27 | - |
dc.date.issued | 2022-06 | - |
dc.identifier.citation | ACS APPLIED MATERIALS & INTERFACES, v.14, no.22, pp.25115 - 25125 | - |
dc.identifier.issn | 1944-8244 | - |
dc.identifier.uri | http://hdl.handle.net/10203/297124 | - |
dc.description.abstract | For rapid and effective hemostasis of uncontrollable bleeding, versatile hemostatic agents have been emerging. Among them, polyphenol-derived adhesives have attracted those hemostatic materials due to instantaneous formation of sticky barriers by robust interactions between the material and the serum proteins from wound. However, a critical challenge in such phenolic materials lies in long-term storage due to spontaneous oxidation under humid environments, leading to changes in hemostatic capability and adhesive strength. Here, we report a transparent hemostatic film consisting of gallol-conjugated chitosan (CHI-G) for minimizing the phenolic oxidation even for 3 months and maintaining strong tissue adhesiveness and its hemostatic ability. The film undergoes a phase transition from solid to injectable hydrogels at physiological pH for efficiently stopping internal and external hemorrhage. Interestingly, the hemostatic capability of the CHI-G hydrogels after 3 month storage depends on (i) the folded microstructure of the polymer with optimal gallol modification and (ii) an initial phase of either a solution state or a solid film. When the hydrogels are originated from the dehydrated film, their successful hemostasis is observed in a liver bleeding model. Our finding would provide an insight for design rationale of hemostatic formulations with long shelf-life. | - |
dc.language | English | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.title | Addressing the Shortcomings of Polyphenol-Derived Adhesives: Achievement of Long Shelf Life for Effective Hemostasis | - |
dc.type | Article | - |
dc.identifier.wosid | 000809967900001 | - |
dc.identifier.scopusid | 2-s2.0-85131759363 | - |
dc.type.rims | ART | - |
dc.citation.volume | 14 | - |
dc.citation.issue | 22 | - |
dc.citation.beginningpage | 25115 | - |
dc.citation.endingpage | 25125 | - |
dc.citation.publicationname | ACS APPLIED MATERIALS & INTERFACES | - |
dc.identifier.doi | 10.1021/acsami.2c03930 | - |
dc.contributor.localauthor | Lee, Haeshin | - |
dc.contributor.nonIdAuthor | Ju, Jaewon | - |
dc.contributor.nonIdAuthor | Jin, Subin | - |
dc.contributor.nonIdAuthor | Kim, Sumin | - |
dc.contributor.nonIdAuthor | Choi, Jae Hyuk | - |
dc.contributor.nonIdAuthor | Lee, Haesung A. | - |
dc.contributor.nonIdAuthor | Son, Donghee | - |
dc.contributor.nonIdAuthor | Shin, Mikyung | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | gallols | - |
dc.subject.keywordAuthor | film-to-hydrogel conversion | - |
dc.subject.keywordAuthor | long shelf-life | - |
dc.subject.keywordAuthor | durable hemostasis | - |
dc.subject.keywordPlus | HYALURONIC-ACID | - |
dc.subject.keywordPlus | CHITOSAN | - |
dc.subject.keywordPlus | CATECHOL | - |
dc.subject.keywordPlus | HYDROGEL | - |
dc.subject.keywordPlus | GALLOL | - |
dc.subject.keywordPlus | STRATEGIES | - |
dc.subject.keywordPlus | PYROGALLOL | - |
dc.subject.keywordPlus | OXIDATION | - |
dc.subject.keywordPlus | STEM | - |
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