DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Jang Hyun | ko |
dc.contributor.author | Kang, In | ko |
dc.contributor.author | Lee, Heung Kyu | ko |
dc.date.accessioned | 2022-06-21T10:02:40Z | - |
dc.date.available | 2022-06-21T10:02:40Z | - |
dc.date.created | 2022-06-21 | - |
dc.date.created | 2022-06-21 | - |
dc.date.created | 2022-06-21 | - |
dc.date.issued | 2022-05 | - |
dc.identifier.citation | FRONTIERS IN IMMUNOLOGY, v.13 | - |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.uri | http://hdl.handle.net/10203/297023 | - |
dc.description.abstract | gamma delta T cells are a distinct subset of T cells expressing gamma delta T cell receptor (TCR) rather than alpha beta TCR. Since their discovery, the critical roles of gamma delta T cells in multiple physiological systems and diseases have been investigated. gamma delta T cells are preferentially located at mucosal surfaces, such as the gut, although a small subset of gamma delta T cells can circulate the blood. Additionally, a subset of gamma delta T cells reside in the meninges in the central nervous system. Recent findings suggest gamma delta T cells in the meninges have critical roles in brain function and homeostasis. In addition, several lines of evidence have shown gamma delta T cells can infiltrate the brain parenchyma and regulate inflammatory responses in multiple diseases, including neurodegenerative diseases. Although the importance of gamma delta T cells in the brain is well established, their roles are still incompletely understood due to the complexity of their biology. Because gamma delta T cells rapidly respond to changes in brain status and regulate disease progression, understanding the role of gamma delta T cells in the brain will provide critical information that is essential for interpreting neuroimmune modulation. In this review, we summarize the complex role of gamma delta T cells in the brain and discuss future directions for research. | - |
dc.language | English | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.title | gamma delta T Cells in Brain Homeostasis and Diseases | - |
dc.type | Article | - |
dc.identifier.wosid | 000808382100001 | - |
dc.identifier.scopusid | 2-s2.0-85131851735 | - |
dc.type.rims | ART | - |
dc.citation.volume | 13 | - |
dc.citation.publicationname | FRONTIERS IN IMMUNOLOGY | - |
dc.identifier.doi | 10.3389/fimmu.2022.886397 | - |
dc.contributor.localauthor | Lee, Heung Kyu | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Review | - |
dc.subject.keywordAuthor | gamma delta T cell | - |
dc.subject.keywordAuthor | central nervous system | - |
dc.subject.keywordAuthor | brain | - |
dc.subject.keywordAuthor | neuroimmunology | - |
dc.subject.keywordAuthor | brain diseases | - |
dc.subject.keywordPlus | CEREBROSPINAL-FLUID | - |
dc.subject.keywordPlus | LINEAGE COMMITMENT | - |
dc.subject.keywordPlus | PERIPHERAL-BLOOD | - |
dc.subject.keywordPlus | IMMUNE-RESPONSE | - |
dc.subject.keywordPlus | ALPHA-BETA | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | TCR | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | FETAL | - |
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