gamma delta T Cells in Brain Homeostasis and Diseases

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dc.contributor.authorPark, Jang Hyunko
dc.contributor.authorKang, Inko
dc.contributor.authorLee, Heung Kyuko
dc.date.accessioned2022-06-21T10:02:40Z-
dc.date.available2022-06-21T10:02:40Z-
dc.date.created2022-06-21-
dc.date.created2022-06-21-
dc.date.created2022-06-21-
dc.date.issued2022-05-
dc.identifier.citationFRONTIERS IN IMMUNOLOGY, v.13-
dc.identifier.issn1664-3224-
dc.identifier.urihttp://hdl.handle.net/10203/297023-
dc.description.abstractgamma delta T cells are a distinct subset of T cells expressing gamma delta T cell receptor (TCR) rather than alpha beta TCR. Since their discovery, the critical roles of gamma delta T cells in multiple physiological systems and diseases have been investigated. gamma delta T cells are preferentially located at mucosal surfaces, such as the gut, although a small subset of gamma delta T cells can circulate the blood. Additionally, a subset of gamma delta T cells reside in the meninges in the central nervous system. Recent findings suggest gamma delta T cells in the meninges have critical roles in brain function and homeostasis. In addition, several lines of evidence have shown gamma delta T cells can infiltrate the brain parenchyma and regulate inflammatory responses in multiple diseases, including neurodegenerative diseases. Although the importance of gamma delta T cells in the brain is well established, their roles are still incompletely understood due to the complexity of their biology. Because gamma delta T cells rapidly respond to changes in brain status and regulate disease progression, understanding the role of gamma delta T cells in the brain will provide critical information that is essential for interpreting neuroimmune modulation. In this review, we summarize the complex role of gamma delta T cells in the brain and discuss future directions for research.-
dc.languageEnglish-
dc.publisherFRONTIERS MEDIA SA-
dc.titlegamma delta T Cells in Brain Homeostasis and Diseases-
dc.typeArticle-
dc.identifier.wosid000808382100001-
dc.identifier.scopusid2-s2.0-85131851735-
dc.type.rimsART-
dc.citation.volume13-
dc.citation.publicationnameFRONTIERS IN IMMUNOLOGY-
dc.identifier.doi10.3389/fimmu.2022.886397-
dc.contributor.localauthorLee, Heung Kyu-
dc.description.isOpenAccessN-
dc.type.journalArticleReview-
dc.subject.keywordAuthorgamma delta T cell-
dc.subject.keywordAuthorcentral nervous system-
dc.subject.keywordAuthorbrain-
dc.subject.keywordAuthorneuroimmunology-
dc.subject.keywordAuthorbrain diseases-
dc.subject.keywordPlusCEREBROSPINAL-FLUID-
dc.subject.keywordPlusLINEAGE COMMITMENT-
dc.subject.keywordPlusPERIPHERAL-BLOOD-
dc.subject.keywordPlusIMMUNE-RESPONSE-
dc.subject.keywordPlusALPHA-BETA-
dc.subject.keywordPlusRECEPTOR-
dc.subject.keywordPlusTCR-
dc.subject.keywordPlusSYSTEM-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusFETAL-
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