Photoinduced alpha-C-H Amination of Cyclic Amine Scaffolds Enabled by Polar-Radical Relay

Cited 2 time in webofscience Cited 0 time in scopus
  • Hit : 55
  • Download : 0
Herein, we report a polar-radical relay strategy for alpha-C-H amination of cyclic amines with N-chloro-N-sodio-carbamates. The relay is initiated by in situ generation of cyclic iminium intermediate using N-iodosuccinimide (NIS) oxidant as an initiator, which then operates through a series of polar (addition and elimination) and radical (homolysis, hydrogen- and halogen atom transfer) reactions to enable the challenging C-N bond formation in a controlled manner. A broad range of alpha-amino cyclic amines were readily accessed with excellent regioselectivity, and the superb applicability was further demonstrated by functionalization of biologically relevant compounds.
Publisher
WILEY-V C H VERLAG GMBH
Issue Date
2022-06
Language
English
Article Type
Article
Citation

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.61, no.25

ISSN
1433-7851
DOI
10.1002/anie.202202971
URI
http://hdl.handle.net/10203/296976
Appears in Collection
CH-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 2 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0