DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeong, Jiung | ko |
dc.contributor.author | Choi, Young Joon | ko |
dc.contributor.author | Lee, Heung Kyu | ko |
dc.date.accessioned | 2022-04-25T06:00:37Z | - |
dc.date.available | 2022-04-25T06:00:37Z | - |
dc.date.created | 2022-04-25 | - |
dc.date.created | 2022-04-25 | - |
dc.date.created | 2022-04-25 | - |
dc.date.issued | 2022-03 | - |
dc.identifier.citation | FRONTIERS IN PHARMACOLOGY, v.13 | - |
dc.identifier.issn | 1663-9812 | - |
dc.identifier.uri | http://hdl.handle.net/10203/295871 | - |
dc.description.abstract | Uncontrolled acute inflammation progresses to persistent inflammation that leads to various chronic inflammatory diseases, including asthma, Crohn's disease, rheumatoid arthritis, multiple sclerosis, and systemic lupus erythematosus. CD4(+) T cells are key immune cells that determine the development of these chronic inflammatory diseases. CD4(+) T cells orchestrate adaptive immune responses by producing cytokines and effector molecules. These functional roles of T cells vary depending on the surrounding inflammatory or anatomical environment. Autophagy is an important process that can regulate the function of CD4(+) T cells. By lysosomal degradation of cytoplasmic materials, autophagy mediates CD4(+) T cell-mediated immune responses, including cytokine production, proliferation, and differentiation. Furthermore, through canonical processes involving autophagy machinery, autophagy also contributes to the development of chronic inflammatory diseases. Therefore, a targeted intervention of autophagy processes could be used to treat chronic inflammatory diseases. This review focuses on the role of autophagy via CD4(+) T cells in the pathogenesis and treatment of such diseases. In particular, we explore the underlying mechanisms of autophagy in the regulation of CD4(+) T cell metabolism, survival, development, proliferation, differentiation, and aging. Furthermore, we suggest that autophagy-mediated modulation of CD4(+) T cells is a promising therapeutic target for treating chronic inflammatory diseases. | - |
dc.language | English | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.title | The Role of Autophagy in the Function of CD4(+) T Cells and the Development of Chronic Inflammatory Diseases | - |
dc.type | Article | - |
dc.identifier.wosid | 000779591700001 | - |
dc.identifier.scopusid | 2-s2.0-85128188566 | - |
dc.type.rims | ART | - |
dc.citation.volume | 13 | - |
dc.citation.publicationname | FRONTIERS IN PHARMACOLOGY | - |
dc.identifier.doi | 10.3389/fphar.2022.860146 | - |
dc.contributor.localauthor | Lee, Heung Kyu | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Review | - |
dc.subject.keywordAuthor | autophagy | - |
dc.subject.keywordAuthor | CD4+T cell | - |
dc.subject.keywordAuthor | asthma | - |
dc.subject.keywordAuthor | Crohn&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | rheumatoid arthritis | - |
dc.subject.keywordAuthor | multiple sclerosis | - |
dc.subject.keywordAuthor | systemic lupus erythematosus | - |
dc.subject.keywordPlus | ANTIOXIDANT SYSTEM | - |
dc.subject.keywordPlus | KINASE VPS34 | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | CONTRIBUTES | - |
dc.subject.keywordPlus | HOMEOSTASIS | - |
dc.subject.keywordPlus | MECHANISMS | - |
dc.subject.keywordPlus | VARIANT | - |
dc.subject.keywordPlus | ATG5 | - |
dc.subject.keywordPlus | MACROAUTOPHAGY | - |
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