(A) study on the change and characterization of chemokine receptors in IL-15-induced, TCR-independent activation of memory CD8+ T cellsIL-15로 유도되는 TCR-독립적 활성 기억 CD8+ T 세포의 케모카인 수용체 변화 및 특성 규명 연구

Cited 0 time in webofscience Cited 0 time in scopus
  • Hit : 305
  • Download : 0
DC FieldValueLanguage
dc.contributor.advisorPark, Su-Hyung-
dc.contributor.advisor박수형-
dc.contributor.authorSeo, In-Ho-
dc.date.accessioned2022-04-21T19:33:31Z-
dc.date.available2022-04-21T19:33:31Z-
dc.date.issued2021-
dc.identifier.urihttp://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=956356&flag=dissertationen_US
dc.identifier.urihttp://hdl.handle.net/10203/295581-
dc.description학위논문(박사) - 한국과학기술원 : 의과학대학원, 2021.2,[iv, 60 p. :]-
dc.description.abstractDuring microbial infection, bystander CD8+ T cells that are not specific to infecting pathogens can be activated by cytokines, such as IL-15. However, the tissue-homing properties of bystander-activated CD8+ T cells have not been elucidated. Here, I examined the effects of IL-15 on the expression of chemokine receptors on CD8+ T cells and their migration. I found that IL-15 up-regulates CCR5 in memory CD8+ T cells in the absence of TCR stimulation and enhances CCR5-dependent migration in vitro and in vivo. IL-15-induced CCR5 up-regulation was abrogated by concurrent TCR stimulation, indicating that CCR5 is up-regulated in bystander-activated CD8+ T cells. Moreover, CCR5 signals increased proliferation and cytotoxic protein expression in IL-15-treated memory CD8+ T cells. CCR5 up-regulation in bystander-activated CD8+ T cells was associated with severe liver injury in patients with acute hepatitis A. Taken together, the results indicate that CCR5 up-regulation by IL-15 mediates the migration of bystander-activated CD8+ T cells.-
dc.languageeng-
dc.publisher한국과학기술원-
dc.subjectInterleukin-15▼abystander CD8+ T cells▼aCCR5▼amigration-
dc.subject인터류킨-15▼a방관자 CD8 T 세포▼aCCR5▼a이동-
dc.title(A) study on the change and characterization of chemokine receptors in IL-15-induced, TCR-independent activation of memory CD8+ T cells-
dc.title.alternativeIL-15로 유도되는 TCR-독립적 활성 기억 CD8+ T 세포의 케모카인 수용체 변화 및 특성 규명 연구-
dc.typeThesis(Ph.D)-
dc.identifier.CNRN325007-
dc.description.department한국과학기술원 :의과학대학원,-
dc.contributor.alternativeauthor서인호-
Appears in Collection
MSE-Theses_Ph.D.(박사논문)
Files in This Item
There are no files associated with this item.

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0