Study of metabolic reprogramming in paclitaxel- and adriamycin- resistant breast cancer cell line

Abstract

Drug resistance is a major cause of cancer recurrence and metastasis. Among various cancers, in breast cancer, where metastasis and recurrence occur at high frequency, efforts are being made to overcome chemoresistance with a polychemotherapy using multiple anticancer drugs at the same time, but the key mechanism that causes drug resistance has not been investigated. Metabolic reprogramming is one of the causes of drug resistance by favoring the differentiation and survival of cancer cells by using a different metabolic pathway from normal cells. To study metabolic reprogramming occurring in paclitaxel- and adriamycin-resistant breast cancer cells, we tried to understand the metabolic network through model simulation and multi-omics analysis, and we tried to identify key reactions and genes that influence drug resistance.