Mechanistic target of rapamycin (mTOR), an important metabolic regulator affects diverse cellular pathways
including cellular growth, aging, and cancer. mTORC pathway is well conserved in multicellular model
organisms and species, including yeast, flies, nematodes, and humans. Increased activation of mTOR accelerates
cell growth and mutations that increase mTOR pathway activity lead multiple diseases including cancer,
metabolic disorders, neurological diseases, and inflammation. Therefore, in vivo animal models are important
for investigating diseases caused by mutation on the mTOR pathway. We have identified a C. elegans
hyperactive mTOR mutation E2594K and found that this mutation that change mTOR physiology and
accelerates C. elegans development