Potential Role of the Gut Microbiome In Colorectal Cancer Progression

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An increasing number of studies have revealed that the progression of colorectal cancer (CRC) is related to gut microbiome composition. Under normal conditions, the gut microbiome acts as a barrier to other pathogens or infections in the intestine and modulates inflammation by affecting the host immune system. These gut microbiota are not only related to the intestinal inflammation associated with tumorigenesis but also modulation of the anti-cancer immune response. Thus, they are associated with tumor progression and anti-cancer treatment efficacy. Studies have shown that the gut microbiota can be used as biomarkers to predict the effect of immunotherapy and improve the efficacy of immunotherapy in treating CRC through modulation. In this review, we discuss the role of the gut microbiome as revealed by recent studies of the growth and progression of CRC along with its synergistic effect with anti-cancer treatment modalities.
Publisher
FRONTIERS MEDIA SA
Issue Date
2022-01
Language
English
Article Type
Review
Citation

FRONTIERS IN IMMUNOLOGY, v.12

ISSN
1664-3224
DOI
10.3389/fimmu.2021.807648
URI
http://hdl.handle.net/10203/294809
Appears in Collection
MSE-Journal Papers(저널논문)
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