For the optimum design of RC frame structures, a simplified but effective discrete optimization algorithm is introduced in this paper. To determine the member force to be based on the design procedure, a plastic analysis considering the sequential development of plastic hinges in beams and columns up to the point of collapse is conducted, with the subsequent optimum design then devised via a direct search method. The construction of a database for predetermined discrete RC sections and interconnections of all design variables in an RC section with a single design variable associated with the section identification number makes it possible to adopt the direct search method instead of a sophisticated mathematical approach that includes many complicated descriptive functions pertaining to RC beams and columns. The use of the plastic analysis also reduces the maximum member force through moment redistribution, and the direct search method makes it possible to find a true optimum section regardless of the assumed initial section. The efficiency and applicability of the introduced algorithm are verified through correlation studies for typical frame structures. In particular, given that all design criteria in design codes and practical limitations required when undertaking the actual design are already considered while determining RC sections in the section database, the obtained results can be directly applied to the creation of designs. In advance, the use of the obtained optimum design results as initial sections in the preliminary design stage will greatly reduce the number of design steps for the determination of RC sections.