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College of Life Science and Bioengineering(생명과학기술대학)Graduate School of Medical Science & Engineering(의과학대학원)MSE-Journal Papers(저널논문)

SUMOylation of ROR alpha potentiates transcriptional activation function

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dc.contributor.authorHwang, Eun Juko
dc.contributor.authorLee, Ji Minko
dc.contributor.authorJeong, Jiyeongko
dc.contributor.authorPark, Joo Hyeonko
dc.contributor.authorYang, Youngko
dc.contributor.authorLim, Jong-Seokko
dc.contributor.authorKim, Jung Hwako
dc.contributor.authorBaek, Sung Heeko
dc.contributor.authorKim, Keun Ilko
dc.date.accessioned2022-02-21T06:42:07Z-
dc.date.available2022-02-21T06:42:07Z-
dc.date.created2022-02-21-
dc.date.created2022-02-21-
dc.date.created2022-02-21-
dc.date.issued2009-01-
dc.identifier.citationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.378, no.3, pp.513 - 517-
dc.identifier.issn0006-291X-
dc.identifier.urihttp://hdl.handle.net/10203/292326-
dc.description.abstractSUMOylation regulates a variety of cellular processes, including control of transcriptional activities of nuclear receptors. Here, we present SUMOylation of orphan nuclear receptor, ROR alpha by both SUMO-1 and SUMO-2. SUMOylation of ROR alpha occurred on the 240th lysine residue at the hinge region of human protein. PIAS family members, PIASx alpha, PIAS3, and PIASy, increased SUMOylation of ROR alpha, whereas SENP2 specifically removed SUMO from ROR alpha SUMOylation-defective mutant form of ROR alpha exhibited decreased transcriptional activity on ROR alpha-responsive promoters indicating that SUMOylation may positively regulate transcriptional function of ROR alpha. (C) 2008 Elsevier Inc. All rights reserved.-
dc.languageEnglish-
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE-
dc.titleSUMOylation of ROR alpha potentiates transcriptional activation function-
dc.typeArticle-
dc.identifier.wosid000262343200037-
dc.identifier.scopusid2-s2.0-57749182667-
dc.type.rimsART-
dc.citation.volume378-
dc.citation.issue3-
dc.citation.beginningpage513-
dc.citation.endingpage517-
dc.citation.publicationnameBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.identifier.doi10.1016/j.bbrc.2008.11.072-
dc.contributor.localauthorLee, Ji Min-
dc.contributor.nonIdAuthorHwang, Eun Ju-
dc.contributor.nonIdAuthorJeong, Jiyeong-
dc.contributor.nonIdAuthorPark, Joo Hyeon-
dc.contributor.nonIdAuthorYang, Young-
dc.contributor.nonIdAuthorLim, Jong-Seok-
dc.contributor.nonIdAuthorKim, Jung Hwa-
dc.contributor.nonIdAuthorBaek, Sung Hee-
dc.contributor.nonIdAuthorKim, Keun Il-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorROR alpha-
dc.subject.keywordAuthorSUMO-
dc.subject.keywordAuthorSUMOylation-
dc.subject.keywordAuthordeSUMOylation-
dc.subject.keywordAuthorUbc9-
dc.subject.keywordAuthorPIAS-
dc.subject.keywordAuthorSENP2-
dc.subject.keywordPlusORPHAN NUCLEAR RECEPTOR-
dc.subject.keywordPlusCONJUGATING ENZYME-
dc.subject.keywordPlusMODIFIER-1 SUMO-1-
dc.subject.keywordPlusPROTEIN SMT3P-
dc.subject.keywordPlusDNA-BINDING-
dc.subject.keywordPlusREQUIRES-
dc.subject.keywordPlusUBC9-
dc.subject.keywordPlusCHOLESTEROL-
dc.subject.keywordPlusANGSTROM-
dc.subject.keywordPlusLIGAND-
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MSE-Journal Papers(저널논문)
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