DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Su Chan | ko |
dc.contributor.author | Park, Il-Geun | ko |
dc.contributor.author | Kim, Hyunkyung | ko |
dc.contributor.author | Lee, Ji Min | ko |
dc.date.accessioned | 2022-02-21T06:41:33Z | - |
dc.date.available | 2022-02-21T06:41:33Z | - |
dc.date.created | 2022-02-21 | - |
dc.date.created | 2022-02-21 | - |
dc.date.created | 2022-02-21 | - |
dc.date.created | 2022-02-21 | - |
dc.date.issued | 2019-04 | - |
dc.identifier.citation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.20, no.7 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | http://hdl.handle.net/10203/292315 | - |
dc.description.abstract | Four members of the retinoic acid-related orphan receptor alpha (ROR alpha) family (ROR alpha 1, ROR alpha 2, ROR alpha 3 and ROR alpha 4) are transcription factors that regulate several processes including circadian rhythm, lipid metabolism, cerebellar development, immune function, and cancer. Only two isoforms, ROR alpha 1 and 4, are specifically co-expressed in the murine and human. In the present study, we identified a specific N-terminal domain (NTD) of ROR alpha 1 that potentiated the downregulation of target genes involved in tumor progression and proliferation, based on results from ROR alpha-deficient mouse embryonic fibroblasts and prostate carcinoma tissues. The hyperactivation of proliferative target genes were observed in ROR alpha-deficient embryonic fibroblasts, and reconstitution of ROR alpha 1 inhibited this activation by a NTD dependent manner. Downregulation of ROR alpha 1 and upregulation of Wnt/beta-catenin target genes were correlated in prostate cancer patients. These findings revealed the control of invasive growth by NTD-mediated ROR alpha 1 signaling, suggesting advanced approaches for the development of therapeutic drugs. | - |
dc.language | English | - |
dc.publisher | MDPI | - |
dc.title | N-Terminal Domain Mediated Regulation of ROR alpha 1 Inhibits Invasive Growth in Prostate Cancer | - |
dc.type | Article | - |
dc.identifier.wosid | 000464977600010 | - |
dc.identifier.scopusid | 2-s2.0-85064928698 | - |
dc.type.rims | ART | - |
dc.citation.volume | 20 | - |
dc.citation.issue | 7 | - |
dc.citation.publicationname | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.identifier.doi | 10.3390/ijms20071684 | - |
dc.contributor.localauthor | Lee, Ji Min | - |
dc.contributor.nonIdAuthor | Kim, Hyunkyung | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | ROR alpha 1 | - |
dc.subject.keywordAuthor | Wnt | - |
dc.subject.keywordAuthor | beta-catenin pathway | - |
dc.subject.keywordAuthor | prostate cancer | - |
dc.subject.keywordAuthor | NTD | - |
dc.subject.keywordPlus | ORPHAN NUCLEAR RECEPTORS | - |
dc.subject.keywordPlus | BETA-CATENIN | - |
dc.subject.keywordPlus | ROR-ALPHA | - |
dc.subject.keywordPlus | TRANSCRIPTIONAL ACTIVATION | - |
dc.subject.keywordPlus | ANDROGEN RECEPTOR | - |
dc.subject.keywordPlus | WNT | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
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